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OpenTrials
Completed

NCT Number: NCT02740595

E-cigarettes and Blood Vessel Function

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.

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Key information

Conditions

Nicotine Dependence Chemically-Induced Disorders Mental Disorders Substance-Related Disorders Tobacco Use Disorder

Age range

21 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UCaliforniaLA

Los Angeles, California, 90095, United States

About this study

Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and undergo a measure of endothelial function called brachial artery flow mediated dilatation (FMD). Additionally, oxidative stress will be measured pre and post exposure.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy

Exclusion criteria

  • Cardiac disease
  • Respiratory disease
  • Diabetes mellitus

Treatment and study plan

one time exposure to e-cig with nicotine

Other

one time exposure to e-cig vapor with nicotine

one time exposure to e-cig without nicotine

Other

one time exposure to e-cig without nicotine

one time exposure to empty e-cig

Other

one time exposure to empty e-cig (sham control

Other names: sham control

Primary outcomes

  1. Flow mediated dilatation (FMD)

    Time frame: 10 minutes after exposure

    FMD is a measure of endothelial function

  2. Paraoxonse

    Time frame: less than 1 hour after exposure

    plasma oxidative stress

Sponsors and collaborators

Lead sponsor

University of California, Los Angeles

Other

Registry information

Official study title

The Effects of Electronic Cigarettes on Endothelial Function and Oxidative Stress

Important dates

Study start
2015
Primary completion
2022
Study completion
2022
First posted
Apr 15, 2016
Registry last updated
Oct 5, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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