Dynamical Electrophysiology and Neuropathology in Lewy's Bodies Disease

Lewy body disease (LBD) is a neurodegenerative disorder that causes cognitive and behavioral problems. However, it is difficult to diagnose, and its pathophysiology is still not fully understood. The usual diagnostic criteria for LBD have excellent specificity but poor sensitivity. In particular, we lack paraclinical tests that can make a significant contribution. LBD patients may exhibit abnormalities in brain activity dynamics, which can be detected by EEG and may be linked to neuronal dysfunctions specific to the disease. The objective of this study is twofold: first, to assess the validity of this observation, that is, to confirm that the observed phenomenon is indeed linked to the pathophysiology of LBD, and second, to clarify the nature of these abnormalities by exploring the brain dynamics of LBD patients in greater detail.

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Key information

Conditions

Lewy Body Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Movement Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Service de psychiatrie de la personne âgée - CHU de Strasbourg - France

Strasbourg, 67091, France

Location status: Recruiting

Location contact

Ludovic DORMEGNY-JEANJEAN, MD

CONTACT

[email protected]

33 3 88 11 69 21

Ludovic DORMEGNY-JEANJEAN, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult subjects (≥18 years old).
Subject who participated in the Alpha-Lewy-MA cohort and underwent RT-QuIC analysis.
Subject who underwent a standard EEG examination at HUS between January 1, 2012, and January 1, 2020.

Exclusion criteria

Subject who expressed opposition to participating in the study.

Treatment and study plan

Primary outcomes

Parameter θ of dynamic fluidity of brain activity

Time frame: Up to 12 months
Parameter θ of dynamic fluidity of brain activity (quantifying the system's ability to move away from its current configuration)

θ is used to measure something specific in the brain: how flexible its activity is.

Quantifying the system's ability to move away from its current configuration:
- In plain words, θ tells us how much the brain can change from its current state.
- High θ → brain is very flexible, can switch between states easily.
- Low θ → brain is rigid, stays in the same pattern longer.

Study contacts

Contact information is provided by the study sponsor or research team.

Ludovic DORMEGNY-JEANJEAN, MD

CONTACT

[email protected]

33 3 88 11 69 21

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Acronym: DYNAPATH-LB

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jan 13, 2026
Registry last updated: Jan 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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