Dynamic Neural Mechanisms of Audiovisual Speech Perception

Understanding speech is one of the most important functions of the human brain. We use information from both the auditory modality (the voice the of person we are talking to) and the visual modality (the facial movements of the person we are talking to) to understand speech. We will use intracranial encephalography to study the organization and operation of the brain during audiovisual speech perception.

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Key information

Conditions

Speech Perception

Age range

21 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

must be undergoing neurosurgery for the treatment of a brain disorder

Exclusion criteria

must have corrected-to-normal vision and hearing

Treatment and study plan

Measurement of brain activity using electrodes.

Other

We will present audiovisual speech and record neural responses.

Primary outcomes

Measurement of neural activity

Time frame: During the procedure.

The name of the measurement is the broadband high-frequency activity (BHA) in the brain in response to audiovisual speech. The unit of measure is % increase in power from pre-stimulus baseline. The name of the measurement tool is intracranial EEG, recordings of the raw voltage signal from each electrode implanted in the brain. The voltage-by-time signal will be converted to spectral space using a wavelet transform, and the magnitude of the power between 70 and 150 Hz inclusive in a time window between 0 ms and 500 ms after stimulus onset will be calculated.

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Collaborators

Baylor College of Medicine
Columbia University

Registry information

Important dates

Study start: 2019
Primary completion: 2026
Study completion: 2026
First posted: Feb 28, 2020
Registry last updated: Sep 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed