Dynamic Network Response to TMS Treatment

Difference Score between pre-TMS and post-TMS on the Hamilton Depression Rating Scale (HAMD).

HAMD: Standard interview for assessing current depressive symptoms from the perspective of the practitioner with 17 and 4 additional items (duration approx. 20 min). For this outcome measure, the first 17 items are used to calculate a sum score for interpretation, because cut-off scores exist for the HAMD-17 version. Higher scores reflect greater symptom intensity. The sum scores range between a minimum of 0 and a maximum of 52.

A sum score ≤ 8 indicates no depression. A sum score between 9-16 indicates mild depression. A sum score between 17-24 indicates moderate depression. A sum score ≥ 25 indicates severe depression.

Difference Score between pre-TMS and post-TMS on the Montgomery-Asberg Depression Rating Scale (MADRS).

MADRS: Standard interview for assessing current depressive symptoms from the perspective of the practitioner with higher sensitivity to change than the HAMD with 10 items (duration approx. 15 min). Higher scores reflect greater symptom intensity. A sum score of the 10 items is calculated for interpretation: The sum scores range between a minimum of 0 and a maximum of 60.

A sum score ≤ 6 indicates no depression. A sum score between 7-16 indicates mild depression. A sum score between 20-34 indicates moderate depression. A sum score ≥ 35 indicates severe depression.

Difference Score between pre-TMS and post-TMS on the Inventory of Depressive Symptomatology Clinician Rated (IDS-C).

IDS-C: Standard interview for assessing current depressive symptoms with higher sensitivity to residual symptoms than the HAMD with 30 items. The sum score for interpretation is calculated using 28 of the 30 items. Higher scores reflect greater symptom intensity. The sum scores range between a minimum of 0 and a maximum of 84. A sum score ≤ 13 indicates no depression. A sum score between 14-25 indicates mild depression. A sum score between 26-38 indicates moderate depression. A sum score ≥ 48 indicates severe depression.

Difference Score between pre-TMS and post-TMS on the Hamilton Anxiety Rating Scale (HAMA). HAMA: Standard interview to assess the severity of anxiety symptoms (duration approx. 5 min). Higher scores reflect greater symptom severity. A sum score of the 14 items is calculated for interpretation: The sum scores range between a minimum of 0 and a maximum of 56. A sum score ≤ 17 indicates mild severity. A sum score between 18-24 indicates mild severity. A sum score between 25-30 indicates moderate to severe. A sum score ≥ 31 indicates severe to very severe.

Difference Score between pre-TMS and post-TMS on the Young Mania Rating Scale (YMRS). YMRS: Standard interview for assessing manic symptoms (duration approx. 10 min). Higher scores reflect greater symptom intensity. A sum score of the 11 items is calculated for interpretation: The sum scores range between a minimum of 0 and a maximum of 60. A sum score ≤ 12 indicates no or minimal manic symptoms. A sum score between 13-19 indicates mild mania or hypomania. A sum score between 20-25 indicates moderate mania. A sum score ≥ 26 indicates severe mania.

Difference Score between pre-TMS and post-TMS on the Beck Depression Inventory Version 2 (BDI-II). BDI-II: Standard self-report questionnaire for assessing the severity of current depressive symptoms (duration approx. 4 min). Higher scores reflect greater symptom intensity. The sum scores range between a minimum of 0 and a maximum of 63. A sum score of the 21 items is calculated for interpretation: A sum score ≤ 13 indicates no or minimal depression. A sum score between 14-19 indicates mild depression. A sum score between 20-28 indicates moderate depression. A sum score ≥ 29 indicates severe depression.

PATHEV questionnaire for patients once before treatment. Expectancy questionnaire for clinician on treatment effect for the patient. Scores on three sub-scales of the Patient Questionnaire on Therapy Expectation and Evaluation (PATHEV). PATHEV: Standard questionnaire to evaluate treatment effect expectations (duration approx 3 min). Higher scores on the sub-scales indicate hope of improvement, fear of change and treatment fit. The sub-scales consist of 4, 3 and 4 items. The sum scores range between a minimum of 11 and a maximum of 55.

18 items on depressive symptoms asked daily via App once a day. The items are a subset of clinically relevant items used in the central DYNAMIC project (DRKS00038256) for daily App assessment. Higher scores reflect greater symptom severity.