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Completed

NCT Number: NCT01368237

Dynamic Myocardial Perfusion Imaging by 320 Multidetector Computed Tomography

Recent advances in technology have resulted in the development of scanners that can image the heart blood vessels within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters. Further advances in technology allow the visualisation of both the blood vessels and the supply of blood to the heart muscle. Here we propose to assess the latest and most powerful computed tomography scanner and compare it to magnetic resonance and conventional coronary angiography.

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Key information

Conditions

Coronary Heart Disease Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Royal Infirmary of Edinburgh

Edinburgh, Scotland, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • referred for invasive coronary angiography because of suspected coronary heart disease

Exclusion criteria

  • inability or unwillingness to undergo computed tomography or magnetic resonance imaging
  • renal failure (serum creatinine >200 micromol/L or estimated glomerular filtration rate <30 mL/min)
  • hepatic failure
  • allergy to iodinated contrast or gadolinium
  • pregnancy
  • contraindication to adenosine infusion
  • inability to give informed consent
  • inability to perform fractional flow reserve during invasive coronary angiography

Treatment and study plan

Computed tomography scan

Radiation

Computed tomography will be performed using a 320 multidetector computed tomography scanner and may include coronary calcium score, coronary angiography and imaging of myocardial perfusion, function and viability.

Primary outcomes

  1. Myocardial perfusion defects defined qualitatively by trained observers and quantitatively by computer software

    Time frame: 1 month

    The primary outcome measure is to establish whether 320-multidetector computed tomography can identify myocardial perfusion defects as compared to the gold standards of 3Tesla magnetic resonance imaging and fractional flow reserve measured during invasive coronary angiography.

Secondary outcomes

  1. Identification of regional wall motion abnormalities qualitatively by trained observers

    Time frame: 1 month

    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.

  2. Identification of infarction qualitatively by trained observers

    Time frame: 1 month

    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.

  3. Identification of regional wall motion abnormalities quantitatively by computer software

    Time frame: 1 month

    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.

  4. Identification of infarction qualitatively by computer software

    Time frame: 1 month

    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Collaborators

  • NHS Lothian

Registry information

Important dates

Study start
2006
Primary completion
2014
Study completion
2017
First posted
Jun 7, 2011
Registry last updated
Jun 25, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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