Skip to main content
OpenTrials
Completed

NCT Number: NCT05866250

Dynamic Change of Doppler-based Renal Resistive Index in Predicting Renal Recovery

The goal of this observational study is to observe the correlation between dynamic changes in the Doppler-based renal resistive index (RI) and the occurrence of persistent acute kidney injury (AKI) in critically ill patients. The main questions it aims to answer are:

* Are dynamic changes of RI within 24 or 48 hours associated with the prognosis of AKI (NO AKI, transient AKI, persistent AKI)? * what are the influencing factors of changes in RI? Participants will measure values of RI in patients at admission (0 hour), after 24 hours and after 48 hours, respectively, and collect characters such as age, sex, vital signs, Apache II, diagnosis, renal function, applied drugs, fluid, 72-hour renal function and renal replacement, followed renal replacement and the mortality rate at 28 days.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Jilin Province People's Hospital, Changchun, Jlin, China

Loading trial locations.

About this study

NO AKI is defined as No AKI occurred within 72 hour after ICU admission; Transient AKI is defined as AKI with recovery, which refers to the reduction in AKI stage ( (i.e., a decrease of serum creatinine, reversal of oliguria without diuretic therapy, and without need for renal replacement therapy) occurring with 72 hour after ICU admission; Persistent AKI is defined as AKI without recovery occurring with 72 hour after ICU admission.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients admitted to the ICU within 24 h of admission.

Exclusion criteria

  • Chronic kidney disease stage III-V;
  • History of kidney transplantation;
  • Previously known renal artery stenosis or renal vein thrombosis；
  • Cardiac arrhythmia precluding renal Doppler measurement;
  • Expected hospital stay < 72 h；
  • Pregnant patients
  • Last, patients with hospital stays < 72 h, since they could not be classified as having transient or persistent AKI according to our definitions, were secondarily excluded.

Treatment and study plan

Doppler-based renal resistive index

Diagnostic Test

The kidney's interlobular or arcuate artery was preferentially selected and measured by pulse-wave Doppler.

Primary outcomes

  1. The prognosis of AKI

    Time frame: 72 hours

    NO AKI, transient AKI, persistent AKI. Transient AKI refers to the reduction in AKI stage ( (a decrease of serum creatinine, reversal of oliguria without diuretic therapy, and without need for renal replacement therapy) occurring with 72 hour after ICU admission. Persistent AKI refers to AKI without recovery occurring within 72 hours after ICU admission.

Secondary outcomes

  1. Recovery of kidney function

    Time frame: 28 days

    A decrease of serum creatinine, reversal of oliguria without diuretic therapy, and without need for renal replacement therapy.

  2. Mortality

    Time frame: 28 days

    Death or suivival

Sponsors and collaborators

Lead sponsor

The First Hospital of Jilin University

Other

Registry information

Official study title

Dynamic Change of Doppler-based Renal Resistive Index in Predicting Renal Recovery From Acute Kidney Injury in Critically Ill Patients: a Prospective Observational Multicenter Study

Acronym: DRRRI

Important dates

Study start
2023
Primary completion
2023
Study completion
2024
First posted
May 19, 2023
Registry last updated
May 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.