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OpenTrials
Completed

NCT Number: NCT06547931

Duffy-null Associated Neutrphil Count (DANC) Pediatric Patients

There are currently no clinical and laboratory data that well characterize this neutropenia associated with the Duffy-null phenotype, particularly for pediatric subjects. In particular there are no data on the frequency of immune neutropenia in DANC neutropenic pediatric subjects.

The goal of this study is to :

* define the frequency of immune neutropenia within the cohort of DANC subjects under study * evaluate the frequency of different degrees of neutropenia (mild-moderate-severe); * evaluate the possible association between different degrees of neutropenia and the presence of infections.

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Key information

Conditions

Neutropenia Autoimmune

Age range

Up to 16 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondazione IRCCS Ca' Granda Ospedale Maggioe Policlinico

Milan, 20122, Italy

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • presence of Duffy-null phenotype

Exclusion criteria

  • absence of Duffy-null phenotype

Treatment and study plan

Data collection and analysis

Other

Retrospective collection of clinical and laboratory data relating to the definition of the nature of neutropenia

Primary outcomes

  1. Immune neutropenia and DANC

    Time frame: Through study completion, an average of 1 year

    Frequency of immune neutropenia, expressed as the percentage of DANC subjects testing positive for anti-neutrophil antibodies out of the total DANC subjects included in the study.

Secondary outcomes

  1. Distribution of mild, moderate and severe neutropenia in DANC children

    Time frame: Through study completion, an average of 1 year

    Frequencies in percentage of mild (1000-1500 neutrophils/ul), moderate (500-1000 neutrophils/ul) and severe (<500 neutrophils/ul) neutropenia within the DANC cohort under study

Other outcomes

  1. Neutropenia severity and infections

    Time frame: Through study completion, an average of 1 year

    Correlation between the severity of neutropenia and the presence of infections.

Sponsors and collaborators

Lead sponsor

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Other

Registry information

Official study title

Retrospective Analysis of a Cohort of Duffy-null Associated Neutrophil Count (DANC) Pediatric Patients

Acronym: DANCChildren

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 9, 2024
Registry last updated
Mar 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.