Dual Triggering in Patients With a High Immature Oocyte Rate

In in vitro fertilization (IVF) cycles, even after adequate triggering, some patients present a high rate of immature oocytes retrieved after controlled ovarian stimulation. In vitro oocyte maturation is still an experimental technique, with poorer results than conventional IVF. For that reason improve in in vivo maturation could have a better impact on reproductive outcome.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–43 year

Sex eligibility

Female

Study type

Observational

About this study

Investigators performed an observational study analyzing the difference in the percentage of mature oocytes retrieved in patients with more than 50% immature oocytes in a previous IVF cycle triggered with human chorionic gonadotropin (rhCG) compared to the rate of mature oocytes retrieved in subsequent cycles, triggered with both gonadotropin-releasing hormone agonist (GnRHa) and (hCG). The main outcome measure was the number and percentage of mature oocytes retrieved.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

BMI of 18-30 kg/m2
Male factor required for ICSI

Exclusion criteria

Treatment and study plan

HCG

Other

Oocyte maturation with hCG

Other names: OVITRELLE (Merck Serono)

hCG + GnRH agonist

Other

Oocyte maturation with hCG + GnRH agonist

Other names: Ovitrelle (Merck Serono) + Decapeptyl (Ipsen Pharma)

Primary outcomes

Metaphase II rate

Time frame: 1 day

Number of metaphase II among total of recovered oocytes

Sponsors and collaborators

Lead sponsor

IVI Madrid

Other

Registry information

Official study title

Dual Triggering With Gonadotropin-releasing Hormone Agonist and Standard Dose Human Chorionic Gonadotropin in Patients With a High Immature Oocyte Rate

Important dates

Study start: 2014
Primary completion: 2014
Study completion: 2015
First posted: Jun 24, 2016
Registry last updated: Jun 24, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed