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OpenTrials
Completed

NCT Number: NCT02397642

Dual Trigger Versus Booster Dose of HCG

To salvage the luteal phase and improve pregnancy rate in antagonist IVF/ICSI cycles triggered with GnRH agonist. Two strategies are compared dual trigger with GnRH agonist plus 1000 IU of HCG or triggering with GnRH and giving a booster dose of HCG (1500 IU) on the day of ovum pickup.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

20 year–37 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

IVF centre, Obstetrics and Gynaecology Department, Cairo University Hospitals (Kasr EL Aini), Cairo, Egypt

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • High responder females undergoing antagonist protocol IVF/ICSI cycle
  • More than 14 MII oocytes
  • Estradiol more than 3500 pg/ml on day of trigger

Exclusion criteria

  • Any other protocol
  • Normal or poor responders

Treatment and study plan

IVF/ICSI

Procedure

Human Chorionic Gonadotropin

Drug

given in different doses and timing to support the luteal phase

Primary outcomes

  1. Clinical pregnancy rate

    Time frame: 1 year

    The number of cycles with a evidence of a gestational sac with fetal pulstaions after 5 weeks from pregnancy test

Secondary outcomes

  1. OHSS rate

    Time frame: 1 year

    The number of cycles with evidence of OHSS

Other outcomes

  1. Chemical pregnancy rate

    Time frame: 1 year

    The numbr of cycles with a positive pregnancy test after 14 days from embryo transfer

  2. Early miscarriage rate

    Time frame: 1 year

    Pregnancies ending with miscarriage before 12 weeks of gestation

  3. Ongoing pregnancy rate

    Time frame: 1 year

    Pregnancies ongoing beyond 12 weeks of gestation

  4. Live birth rate

    Time frame: 1 year

    Pregnancies ending in a live birth

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Collaborators

  • Adam International Hospital
  • Nile Ivf Center, Cairo, Egypt

Registry information

Official study title

Dual Trigger Versus Booster Dose of HCG on Ovum Pickup Day in Antagonist IVF/ICSI Cycles Triggered With GnRH Agonist in High Responder Females to Salvage the Luteal Phase

Important dates

Study start
2015
Primary completion
2018
Study completion
2018
First posted
Mar 25, 2015
Registry last updated
Jan 29, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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