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Completed

NCT Number: NCT02858622

Dual Transversus Abdominis Plane Block in Pediatric Renal Transplant: Effect on Pain Control

Alleviating pain in children undergoing renal transplant is extremely challenging. Large incisions as those of renal transplant (Gibson's incision) require special techniques of pain control that don't affect hemodynamics or renal function. Since the transplant incision doesn't cross midline; a dual-TAP block is thought to be effective in providing pain control in such procedure as it will anesthetize the dermatomes T6-T12, the muscles of the anterior abdominal wall together with the underlying parietal peritoneum.

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Key information

Conditions

Renal Failure Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Renal Insufficiency Signs and Symptoms Urogenital Diseases Urologic Diseases

Age range

3 year–16 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of medicine, Cairo University

Cairo, 11562, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 3-16 years
  • end stage renal disease
  • no known allergy to bupivacaine
  • both sexes

Exclusion criteria

  • known allergy to bupivacaine

Treatment and study plan

Bupivacaine

Drug

bupivacaine 0.25% at a dose 2 mg/kg in the transversus abdominis plane

Pethidine

Drug

pethidine intravenous at a dose 1mg/kg when pain score more than 5 postoperative rescue analgesia

perfalgan

Drug

intravenous paracetamol

Fentanyl

Drug

Primary outcomes

  1. total dose of rescue analgesia

    Time frame: from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours

    pethidine given as rescue analgesia postoperative.

Secondary outcomes

  1. pain scoring system (objective behavioural pain score)

    Time frame: from the time of transfer to the nephrology ICU, every hour for the first 24 hours postoperative

  2. Intraoperative blood pressure

    Time frame: from the induction of anesthesia till end of surgery at half an hour intervals average duration is 4 hours

    measure systolic and diastolic blood pressure

  3. postoperative blood pressure

    Time frame: from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours

    record systolic and diastolic blood pressure every hour for the first 24 hours postoperative

  4. postoperative heart rate

    Time frame: from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours

  5. intraoperative heart rate

    Time frame: from the induction of anesthesia till end of surgery at half an hour intervals average duration is 4 hours

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Unilateral Dual Transversus Abdominis Plane Block in Pediatric Renal Transplant: A Randomized Control Study

Important dates

Study start
2016
Primary completion
2019
Study completion
2019
First posted
Aug 8, 2016
Registry last updated
May 7, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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