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OpenTrials
Completed

NCT Number: NCT04064463

Dual Reinforcement Contingency Management for Alcohol Use Disorders

Phosphatidylethanol (PEth) is a direct biomarker of alcohol that can detect moderate to heavy drinking with high sensitivity and specificity over 3-week periods. Reinforcing negative PEth results alongside attendance may increase the proportion of participants who respond to CM during and post treatment. In the proposed study, the investigators will collect PEth samples every 3 weeks for 12 weeks in 150 participants initiating outpatient treatment for alcohol use disorders. Using a two-group randomized design, participants will be assigned to standard care with PEth monitoring alone or with CM for attending treatment and submitting PEth negative samples. Compared to standard care and monitoring, the investigators expect that the CM intervention will result in greater attendance, more PEth negative samples, and higher proportions of self-reported non-drinking days, along with lower proportions of heavy drinking days, over the short term and the long term, measured throughout a 12-month follow-up. The investigators anticipate that the reinforcement intervention may decrease other drug use and sexual risk behaviors that spread HIV, reduce psychiatric symptoms, and improve quality of life as well.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The Village

Hartford, Connecticut, 06105, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • in intensive outpatient treatment
  • DSM-5 diagnosis of an alcohol use disorder

Exclusion criteria

  • have a condition that may hinder study participation

Treatment and study plan

Standard Care

Behavioral

standard treatment for substance use disorders, along with sample monitoring

Contingency Management

Behavioral

Participants can earn reinforcement for attending group and abstinence from alcohol

Primary outcomes

  1. Group attendance

    Time frame: 12 weeks

    longest consecutive days attended groups

  2. Alcohol abstinence

    Time frame: 12 weeks

    number of negative PEth samples

Sponsors and collaborators

Lead sponsor

UConn Health

Other

Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Registry information

Acronym: Peth

Important dates

Study start
2020
Primary completion
2025
Study completion
2025
First posted
Aug 22, 2019
Registry last updated
Feb 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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