DSM-5 Personality Disorders in Adults With Autism

Rationale: Self-report measures are frequently used for research and clinical assessments of adults with autism spectrum disorder (ASD). However, there has been little research examining agreement between self-report and informant-report in this population. Reliable self-report measures are essential for conducting research with and providing high quality clinical services for adults with autism spectrum disorder.

Objective: This study aims to examine the usefulness of self-report of DSM-5-TR PD traits in adults with ASD compared to informant-reports by administering the self-report screening measure of the Structured Clinical Interview for DSM-5 Screening Personality Questionnaire (SCID-5-SPQ).

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Key information

Conditions

Autism Spectrum Disorder Autistic Disorder Child Development Disorders, Pervasive Mental Disorders Neurodevelopmental Disorders Personality Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Sarr - Parnassia Groep Antes

Rotterdam, Netherlands

Location status: Recruiting

Location contact

Thomas Kramer, MSc

CONTACT

[email protected]

088 358 1616

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Inclusion criteria for ASD participants: (1) primary diagnosis of ASD according to the DSM-5-TR, (2) age 18+ years, (3) no intellectual disability, and (4) at least having completed a primary and secondary education.

Inclusion criteria

for informants:

Participants were asked to identify individuals who knew them well and were capable of providing accurate descriptions of their personality traits, preferably informants that cohabited with the participants. When cohabitants were unavailable, participants were asked to identify "the person who knows you best." Additionally, eligibility of informants for inclusion required that, historically, the informant and the participant talked at least monthly and interacted face-to-face at least yearly.

Exclusion criteria

Exclusion criteria for ASD participants: (1) no ASD diagnosis, (2) current substance abuse, (3) psychotic disorders, (4) schizophrenia, (5) eating disorder, (6), mental retardation (IQ<80), (7) suicidal ideations and (8) age <18 years.

Exclusion criteria

for informants: (1) age <18 years, (2) intellectual disability, and (3) not being able to state and/or recognize psychological and problematic functioning of their participating relative with ASD.

Treatment and study plan

Structured Clinical Interview for DSM-5 Screening Personality Questionnaire (SCID-5-SPQ).

Other

Screening questionnaire

Primary outcomes

Score SCID-5-PD

Time frame: 1 day

The main study parameters are the item scores on the Structured Clinical Interview for DSM-5 Personality Disorders (SCID-5-PD). The participant can score with Yes and No on the questions. The scoring parameters are 0 (No) and 1 (Yes). This is for all items. A higher score means that the participant scores on that personality item.

Sponsors and collaborators

Lead sponsor

Parnassia Groep

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2027
Study completion: 2027
First posted: Dec 10, 2024
Registry last updated: Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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