Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine

Inclusion criteria

• Male or female volunteers 18- 80 years of age and in general good health.
• Willing and able to understand and sign the informed consent form.
• Subjects currently taking at least two medications known to cause xerostomia (dry mouth) as a side effect for the last three months.
• Be willing to conform to the study protocol and procedures.
• Polypharmacy subjects must score 4 or more on the VAS scale of 0-10 ("How severe is your dryness right now?").
• Flow of 5 minutes unstimulated saliva should be below 0.16 ml/min.
• No known history of allergy to personal care/consumer products or their ingredients, relevant to any ingredients in the test products as determined by the study examiner.
• Minimum of 10 teeth

Exclusion criteria

• Subjects unable to understand or unwilling to sign the informed consent form.
• Medical condition which requires premedication prior to dental visits/procedure.
• Active disease of the hard or soft oral tissues.
• History of salivary gland disease such as Sjogren's syndrome, Sarcoidosis, or Head and Neck Radiation Therapy.
• Use of antibiotics or antimicrobial drugs within 30 days prior to study start.
• Participation in any other clinical study within 1 week prior to enrollment into this study.
• Subjects who must receive dental treatment during the study dates.
• Immunocompromised individuals (HIV, AIDS, immunosuppressive drug therapy).
• Presence of orthodontic bands.
• Current smokers (if former smoker, should have stopped at least 1 month prior to Visit 1)
• Use of pilocarpine or other cholinergic stimulating receptor actives prescribed after study enrollment or whose medication dose increases (stable dose for 3 months).
• People on hormone therapy
• Pregnant or lactating subjects.
• Medical condition which prohibits not eating/drinking or chewing gum for four (4) hours prior to your scheduled visits;
• Subjects who have an infectious disease and/or other blood borne diseases (Hepatitis series, HIV, tuberculosis).