Dry Eye Disease With Isotretinoin ISOTRETINOIN

The study aims to explore the effects of isotretinoin therapy on the dry eye parameters in acne vulgaris patients & determine if it is dose-dependent or not.

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Key information

Conditions

Acne Vulgaris Acneiform Eruptions Sebaceous Gland Diseases Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Observational

About this study

To measure the tear film, the eye lid thickness, the meibomian gland function and to do objective tests for comparison

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Moderate to severe acne on isotretinoin

Exclusion criteria

Occular diseases causing dry eye
Pregnant females

Treatment and study plan

Ocular Surface Disease Index (OSDI) questionnaire

Diagnostic Test

The OSDI is a validated, self-administered questionnaire for assessing the presence and severity of ocular surface disease symptoms. The OSDI questionnaire includes 12 questions about the respondent's past week experience with the ocular symptoms, vision-related function, and environmental triggers

Primary outcomes

Total ocular surface disease index (OSDI) SCORE

Time frame: 3 months

Total OSDI score ranged from 0 to 100 with means greater symptom severity

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Digital Assessment of Dry Eye Diseases in Acne Vulgaris Patients Receiving Isotretinoin Therapy

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Dec 10, 2024
Registry last updated: May 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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