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NCT Number: NCT05609864

Drug Wastage : Observational Study in the Operating Rooms of France

Environmental awareness is leading medical field to question its responsibility and possibilities for action.

Drug residues can have a major environmental impact as per their bioaccumulation, toxicity and persistence characteristics, depending on where they are discarded. In France, drug residues should be disposed of by incineration, but in practice this is not systematic. Moreover, data on drug wastage in the operating rooms by anesthesia department are rare.

The GAME-OvBLOC observational study aim to evaluate drug wastage in the operating rooms by anesthesia department in France and to propose ways of improving health care practices.

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Key information

Conditions

Drug Use

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier de Cannes, Cannes, Alpes-Maritimes, France

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About this study

Observational study with data collection over a 24-hour business day. Data collected refer to healthcare team's practices and patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients who will need an anesthesia act in operating room during a 24 hours period

Exclusion criteria

  • Patient opposition to participate in the study or parents opposition if the patient is a child or patient family opposition if the patient is not capable of being informed

Treatment and study plan

Quantification of injectable drugs wastage

Other

Drugs are prescribed at discretion of physicians. For each patient who have anesthesia in the operating room, all labelled syringes having contained drugs (name + dilution) are collected and analyzed.

Primary outcomes

  1. Ratio of overall wastage in milliliter (mL) of prepared and discarded injectable drugs, to overall volume in milliliter (mL) of prepared injectable drugs

    Time frame: 24 hours

    Wastage is defined as : any prepared and unused drug that remains in syringe

Secondary outcomes

  1. Reason for discarding drug residues

    Time frame: 24 hours

    The reason of waste full syringe will be noticed : 1/ prepared in advance and not used ; 2/ prescription change ; 3/ preparation error ; 4/ other reason

  2. Describe drug wastage for each kind of surgery/anesthesia

    Time frame: 24 hours

    Drug wastage according to type of surgery and anaesthesia

  3. Drug residues discarding process

    Time frame: 24 hours

    Questionnaire on nursing practices on the choice of waste disposal circuits according to drugs

  4. Cost of overall injectable drugs wastage

    Time frame: 24 hours

    Estimated cost of drug residues will be evaluated for each drug by the following formula :

    volume of discarded injectable drugs x theoretical price

  5. Describe drug wastage for each age group

    Time frame: 24 hours

    Drug wastage according to the following age groups : adult (≥18 years old) and pediatrics (< 1 year old, 1-5 years old, ≥ 6 years old)

  6. Describe waste and environmental impact of used plastic syringes

    Time frame: 24 hours

    Number and volume of used syringes, use of pre-filled syringes, refilling of syringes and multi-patient use.

    Environmental impact is indirectly assessed by type of plastic used and the transport distance from the production site to France.

  7. Use of alternative to injectable drugs

    Time frame: 24 hours

    Alternatives : local anaesthesia and anaesthetic gases

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

Other

Collaborators

  • Sainte-Anne Military Teaching Hospital

Registry information

Acronym: GAME-OvBLOC

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Nov 8, 2022
Registry last updated
Jul 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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