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NCT Number: NCT05223400

Drug Use Evaluation of Clindamycin in Critical Care Units in Alexandria Main University Hospital

Irrational use of antibiotics is a one of the main health system problems,it leads to antibiotic resistance,increasing antibiotics side effects and the total cost. This study is a medication use evaluation study aims to evaluate intravenous clindamycin prescribing practice in critical care units in Alexandria Main University Hospital.

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Key information

Conditions

Infection, Bacterial Bacterial Infections Bacterial Infections and Mycoses Infections

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of Mdicine

Alexandria, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults 18 years old or more .
  • Patients on clindamycin as an empirical treatment.
  • Patients started clindamycin as an emperical treatment in other departments but the physician approved to continue it in critical care.

Exclusion criteria

  • Children (less than 18 years old)
  • Patients started clindamycin as a defenitive treatment (based on microbiological culture results).

Treatment and study plan

Clindamycin Injection

Drug

it is a clindamycin use evaluation study

Primary outcomes

  1. the number of prescriptions with appropriate indications of clindamycin will be counted during the retrospective observation of all prescriptions

    Time frame: 1 month

    appropriateness of clindamycin indication will be determined according to IDSA guidelines.

Secondary outcomes

  1. the number of prescriptions with duplication of therapy with clindamycin will be counted during the retrospective observation of all prescriptions

    Time frame: 1 month

    duplication of therapy means prescribing of clindamycin concurrently with another antibiotic to target the same microorganism.

  2. the number of patients who had diarrhea as a main side effect of clindamycin

    Time frame: 1 month

    diarrhea is a main side effect of clindamycin so in the study the number of patients who had diarrhea will be counted during the retrospective observation of all prescriptions

  3. the number of patients who had severe drug interactions with clindamycin

    Time frame: 1 month

    in the study the number of patients who severe clindamycin drugs interactions will be counted during the retrospective observation of all prescriptions

  4. Total clindamycin DDD defined daily doses and clindamycin defined daily doses per 1000 patients days.

    Time frame: 1 month

    Defined daily doses measurement of a drug is an indicator put by WHO , it indicates the consumption of this drug in a hospital or a department and defined daily doses per 1000 patients days indicates the consumption of this drug in relation to the total number of patients in a certain period of time.

  5. to calculate the total cost of clindamycin.

    Time frame: 1 month

    The cost of clindamycin treatment courses of all patients will be calculated in the Egyptian pound

Sponsors and collaborators

Lead sponsor

Alexandria University

Other

Registry information

Official study title

Drug Use Evaluation Study of Clindamycin in Critical Care Units in Alexandria Main University Hospital

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Feb 4, 2022
Registry last updated
Feb 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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