Drug Interactions From Simultaneous Administration Of Metformin And GSK189075 To Subjects With Type 2 Diabetes

Inclusion criteria

• Have Type 2 diabetes mellitus.
• Have a Body Mass Index within range 22 to 35kg/m2 inclusive.
• Females who meet above criteria must be physiologically incapable of becoming pregnant (i.e., surgically sterilized, or post-menopausal per protocol definition).

Exclusion criteria

• Are currently taking insulin therapy.
• Have any disease (such as heart, liver, blood, nervous system, or kidney disease, or cancer).
• Have a history of stomach, liver, kidney, or other disease that with interfere with taking the study drug.
• Are currently using diuretics, oral or injectable corticosteroids (inhaled & intranasal corticosteroids are permitted), or other medications that would cause you to deplete your fluid balance in your body; currently taking stable regimens for heart conditions; currently using prescription or non-prescription drugs within 7 days of starting the study that may interfere with the study drug.
• Would donate more than 450 ML of blood over a 2 month period.
• Physician does not think it is a good idea for you to participate in the trial. - Had a urinary tract infection or bladder infection in the last month. - Are currently drinking more than 2 beers, 1 glass of wine, or 1 glass of spirits daily.
• Have a positive urine drug screen test.
• Plan to change your smoking habits during the course of the trial.
• Have Hepatitis C, Hepatitis B, or HIV. - Have a lab or EKG abnormality. - High or low blood pressure.
• Have used of any investigational drug or device during the study or within 30 days prior to 1st dosing of study medication.
• Are a male subject unwilling to abstain or use protection during intercourse.