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OpenTrials
Completed

NCT Number: NCT02851238

Driving Pressure and Postoperative Pulmonary Complications

This study aims to prove that driving pressure limited ventilation is superior in preventing postoperative pulmonary complications to existing protective ventilation.

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Key information

Conditions

One-Lung Ventilation Driving Pressure Postoperative Respiratory Complications

Age range

19 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Samsung medical center

Seoul, 135-710, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults greater than or equal to 19 years
  • Patient who undergoes one-lung ventilation for thoracic surgery

Exclusion criteria

  • The American Society of Anesthesiologists (ASA) Physical Status classification greater than or equal to 4
  • Patient who is contraindicated with application of positive end expiratory pressure
  • Patient who rejects being enrolled in the study

Treatment and study plan

Driving pressure limited ventilation

Other

Positive end expiratory pressure is adjusted to minimize driving pressure, plateau pressure minus end expiratory pressure from 2 to 10 cmH2O during one-lung ventilation

Primary outcomes

  1. The incidence of postoperative pulmonary complications

    Time frame: within the first 3 days after surgery

    Patient is regarded to have postoperative pulmonary complication when 4 or more positive variables exists according to Melbourne Group Scale.

Secondary outcomes

  1. Partial pressure of oxygen in arterial blood

    Time frame: during surgery

  2. The ratio of partial pressure arterial oxygen and fraction of inspired oxygen

    Time frame: on the first postoperative day

    The ratio will be obtained from the first arterial blood gas analysis on the first postoperative day.

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Official study title

Driving Pressure Limited Ventilation Decreases Postoperative Pulmonary Complications in One-Lung Ventilation: Randomized Controlled Study

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Aug 1, 2016
Registry last updated
Oct 9, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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