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Completed

NCT Number: NCT04387097

Drip-infusion of Remifentanil for RIH

The development of remifentanil-induced hyperalgesia (RIH) is an unpleasant experience for surgical patients. An alternative management, gradual withdrawal of remifentanil was effective in prevention of RIH. The investigators designed a simple modality to assess if under withdrawal of remifentanil and further drip-infusion of remifentanil immediately after extubation affected postoperative pain score, the requirement of rescue analgesics, and adverse effects.

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Key information

Conditions

Hyperalgesia Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Sensation Disorders Signs and Symptoms Somatosensory Disorders

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

TriService General Hospital

Taipei, 11490, Taiwan

About this study

In clinical practice, the gradual withdrawal of remifentanil during surgery is unsatisfied. Thus, the investigators conducted a simple modality in a single center retrospective cohort study to assess how under baseline gradual withdrawal of remifentanil and further drip infusion of remifentanil immediately after extubation affected postoperative pain score and use of analgesics.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society of Anesthesiologists (ASA) score of I-III patients receiving total intravenous anesthesia

Exclusion criteria

  • The use of inhalation agents or propofol combined with inhalation anesthesia
  • Pregnancy
  • Previous substance abuse
  • Known allergies to opioids, propofol or any drugs used in the study
  • History of neuropsychiatric disorder
  • Age < 20 years or > 80 years

Treatment and study plan

Remifentanil

Drug

postoperative drip-infusion of remifentanil

Other names: drip-infusion

Primary outcomes

  1. comparison of the numeric rating scale (NRS) between 2 groups

    Time frame: one hour

    NRS scores is labeled from zero to ten, with zero being an example of someone with no pain and ten being the worst pain possible.

  2. requirement for rescue analgesics

    Time frame: one hour

    postoperative requirement for rescue analgesics

Secondary outcomes

  1. type of surgery

    Time frame: three hours

    type of surgery in both groups

  2. surgical site

    Time frame: three hours

    surgical site in both groups

Sponsors and collaborators

Lead sponsor

Tri-Service General Hospital (TSGH)

Other

Registry information

Official study title

Postoperative Drip-infusion of Remifentanil for Preventing Remifentanil-induced Hyperalgesia- a Retrospective Observative Study

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
May 13, 2020
Registry last updated
May 15, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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