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Completed

NCT Number: NCT05673395

Drinking Effect of Electrolyzed Alkaline Reduced Water on Oxidative Stress and Fatigue After Intense Exercise

The goal of this clinical trial is to test the drinking effect of electolyzed alkaline reduced water (ARW) generated from alkaline ionizer (CGM MWPI-2101) on oxidative stress and fatigue after high-intensity exercise in healthy people. The main question[s] it aims to answer are:

* [question 1] Can pH 9.5 EARW reduce oxidative stress compared to purified water (PW) * [question 2] Can pH 9.5 EARW decrease fatigue markers in blood

Participants will drink water from the experimental device after high-intensity exercise. Blood sample will be collected before exercise, after highly intensive exercise, and after then 15 min. of drinking water.

Researchers will compare EARW group and PW group to see the anti-oxidative and anti-fatigue effects.

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Key information

Conditions

Oxidative Stress

Age range

19 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wonju Severance Christian Hospital

Wŏnju, Ganwon-do, 26426, South Korea

About this study

This study was designed as a randomized, controlled, crossover, double-blind clinical trial with a single intervention of ARW intake (pH 9.5, 10 mL/kg body weight) after highly intense exercise.

The participants were divided into two groups, wherein they consumed either purified water (PW group) or EARW (EARW group). Blood samples were collected before exercise, immediately after exercise, and 15 min after drinking water.

For the anti-oxidative effect, ROS, NO, GPx, and MDA levels were measured. For the anti-fatigue effect, latate, lactate dehydrogenase, phosphate and calcium were measured.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy male participants aged 19-25 years
  • physically active with a normal body mass index (BMI)
  • had not smoked for 3 months or consumed alcohol for more than a week prior to the start of the study.

Exclusion criteria

  • any kind of visible or known disease
  • hypertension,
  • musculoskeletal injuries in the previous three months,
  • breathing difficulties,
  • metabolic diseases,
  • autoimmune disease,
  • rash,
  • urticaria.

Treatment and study plan

Electrolyzed alkaline reduced water generator

Device

Participants drink water (10 mL/kg body weight) generated from the device after intensive excercise.

Other names: Electrolyzed alkaline ionizer (CGM MWPI-2101

Primary outcomes

  1. EARW consumption is effective in reducing oxidative stress

    Time frame: 15 minutes

    Reactive oxygen species, nitric oxide, glutathione peroxidase, malondialdehyde

Secondary outcomes

  1. The effects of EARW consumption on exercise-induced fatigue markers in healthy young adults

    Time frame: 15 minutes

    Lactate levels, phosphate levels, cytokines

Sponsors and collaborators

Lead sponsor

Kyu Jae Lee

Other

Collaborators

  • Ceragem Inc.

Registry information

Official study title

Effects of Alkaline-reduced Water Generated From Electrolyzed Device (CGM MWPI-2101) on High-intensity Exercise-induced Oxidative Stress and Fatigue in Young Male Healthy Adults: Controlled, Randomized, Double-blind Clinical Trial

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Jan 6, 2023
Registry last updated
Jan 17, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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