DRIIVE (Data and Research on Interventions to Improve the Vehicular Environment)

DRIIVE (Data and Research on Interventions to Improve the Vehicular Environment) is a community-engaged translational pilot project that will utilize a three parallel arm design to obtain preliminary data on associations between Particulate Matter (PM)/air pollution and physiologic measurements and biomarkers in taxi drivers, and to determine the impact of a HEPA filter (to remove PM and volatile organic compounds) intervention on such physiologic measurements and biomarkers. DRIIVE is funded by the New York State Department of Health Empire Clinical Research Investigator Program (ECRIP), which trains physicians in clinical research in New York. Drivers will be randomized to one of two groups: Intervention or Wait-list Control. In total, two groups of 14 participants in each group will be recruited: 1) Wait List Control group, who will receive a HEPA filter at the end of the 1 month participation period, and 2) Intervention group, who will receive a HEPA filter two weeks into their participation period. The project will be completed within a 2 year timeframe.

Inclusion criteria

Drivers:

• Full-time New York City cab drivers;
• Non Smokers (assessed by modified BRFSS smoking question within screening tool) ;
• Male;
• Between the ages of 21 and 90;
• No immediate plans (within the next 3 months) to leave the City for vacation or for trips back to their home country
• Driver for at least 3 years*;
• Driving schedule does not include overnight shifts, nor does driver have an additional job overnight;
• Own a smart phone (in order to collect heart rate variability data)
• Should self-report at least "Very well" level of English fluency (according to the standard US census question)
• Have working cigarette lighter receptacle/socket inside taxi cab *The requirement to have worked at least 3 years in the U.S. should minimize any acute health effects/disease due to high levels of contaminants associated with country of origin

Exclusion criteria

Drivers:

• Smoker or uses smokeless tobacco products;
• Resides in a smoking household (where 1 or more household members smoke);
• Has a sleep disorder (including insomnia, delayed sleep phase syndrome (DSPS), narcolepsy, night terror, sleep apnea, sleep walking);
• Has a current or previous diagnosis of any type of cancer;
• Has a diagnosis of an inflammatory, autoimmune, or chronic infectious disease (including rheumatoid arthritis, lupus, chronic liver disease, multiple sclerosis, fibromyalgia, inflammatory bowel disease, psoriasis, HIV);
• Has a serious cardiopulmonary medical condition (including cardiovascular disease, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), restrictive lung disease, interstitial lung disease, asthma, acute or chronic bronchitis, cystic fibrosis, pneumonia, tuberculosis, pneumoconiosis, pulmonary hypertension, pulmonary embolism, pleural effusion, pneumothorax, obesity hypoventilation syndrome, neuromuscular lung disease).
• Self reports -well‖ level of English fluency and indicates a preference for an interpreter.