NCT Number: NCT04251143
The purpose of this study is long-term follow up of patients with corneal diseases to analyze the quality of surgical interventions and diagnosis. Corneal ectasia, especially keratoconus, is a corneal disease that leads to an irreversible loss of visual acuity while the cornea becomes steeper, thinner and irregular. For these patients, surgical intervention (e.g. corneal cross-linking) is performed, in case of disease progression. Overall, a long-term follow up is needed to evaluate an early disease progression as well as corneal stability after surgical intervention.
Interested in participating?
Request Info18 year–65 year
All sexes
Observational
Dresden, Saxony, 01307, Germany
Location status: Recruiting
Janine Lenk, MD
SUB_INVESTIGATOR
Naim Terai, MD
SUB_INVESTIGATOR
Robert Herber
CONTACT
Corneal ectasia (e.g. keratoconus) is a corneal disease that is characterized by irregular steepening of corneal curvature, stromal thinning and reduced biomechanical properties. As a result of this, visual acuity is reduced and can improved by spectacles in early state or with rigid gas permeable contact lenses in mild as well as advanced stage of the disease. Furthermore, in moderate and advanced cases stromal scarring occurs that affected the vision negatively. Therefore, a corneal transplantation is needed. Since the introduction of corneal cross-linking, the amount of corneal transplantations has been reduced. It is necessary to perform closely examinations to detect the progression of the disease as well as post-operatively follow-ups to confirm treatment success.
Parameters being analyzed are:
Age, sex, refraction, family history, known duration of ectasia, previous ocular surgery, systemic diseases, systemic and topical medication;
biomicroscopy, anterior optical coherence tomography (OCT), Scheimpflug-based tomography (Pentacam), Biomechanical assessment (Ocular Response Analyzer and Corneal Visualization with the Scheimpflug Technology), optical biometry, confocal microscopy, endothelium cell count.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
UV-A Irradiation and riboflavin
Detailed Information about corneal tomography is used for diagnosis
Time frame: 15 years
To find the best follow-up intervals for keratoconus patients with or without progression of the disease
Time frame: 15 years
To find the best follow-up intervals for keratoconus patients after surgical Intervention.
Time frame: 15 years
What is the best treatment option for the individual patient?
Contact information is provided by the study sponsor or research team.
Technische Universität Dresden
Other
Dresden Corneal Disease and Treatment Study - Analysis for Quality Inspection of Follow-up and Treatment Procedures of Corneal Diseases of the Department of Ophthalmology (University Hospital Carl Gustav Carus Dresden)
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT04475900
Astigmatism, Corneal Astigmatism
Dresden, Saxony, Germany
View Trial DetailsNCT00567671
Corneal Diseases, Corneal Ectasia
Atlanta, Georgia, United States
View Trial DetailsNCT04094090
Corneal Diseases, Corneal Ectasia
San Francisco, California, United States
View Trial DetailsNCT07474870
Corneal Diseases, Corneal Ectasia
Palo Alto, California, United States
View Trial Details