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Completed

NCT Number: NCT00446212

Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

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Key information

Conditions

Anaesthesia

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Royal Melbourne Hospital, Parkville, Victoria, Australia

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About this study

Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female patients
  • Age between 18 and 50 years
  • Presenting for elective surgery under general anaesthesia

Exclusion criteria

  • Inadequate English language comprehension
  • Major drug abuse problem

Treatment and study plan

Propofol

Drug

target controlled infusion of propofol

Desflurane

Drug

Anaesthetic maintenance with desflurane

Primary outcomes

  1. Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire

    Time frame: recovery room stay

Sponsors and collaborators

Lead sponsor

Melbourne Health

Other

Registry information

Important dates

Study start
2006
Primary completion
2008
Study completion
2008
First posted
Mar 12, 2007
Registry last updated
May 30, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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