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NCT Number: NCT07022704

Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial

Researchers aim to evaluate the impact of doxapram administration on diaphragmatic excursion in chronic obstructive pulmonary disease (COPD) patients undergoing spontaneous breathing trial

Recruiting

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Key information

Conditions

COPD Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Mechanical Ventilation Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases Weaning From Mechanical Ventilation

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Cairo University

Cairo, Cairo Governorate, 6890, Egypt

Location status: Recruiting

Location contact

Cairo University

CONTACT

[email protected]

01007174836

About this study

doxapram will be administered intravenously (IV) during spontaneous breathing trial. diaphragmatic excursion will be evaluated by an expert in respiratory muscle ultrasound

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with moderate to severe chronic obstructive pulmonary disease undergoing spontaneous breathing trial

Exclusion criteria

  • Refusal Allergy to doxapram neuromuscular disorders inability to evaluate the diaphragm

Treatment and study plan

Doxapram

Drug

Doxapram will be given as 1.5 mg/kg will be given 10 minutes after the initiation of SBT

Primary outcomes

  1. • Diaphragmatic excursion in mm

    Time frame: before and 10 minutes after doxappram

Secondary outcomes

  1. Arterial blood gases

    Time frame: before and 10 minutes after doxapram

  2. Respiratory rate

    Time frame: before and 10 minutes after doxapram

Study contacts

Contact information is provided by the study sponsor or research team.

Mina Helmy, MD

CONTACT

[email protected]

+201007174836

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

The Influence of Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial: a Prospective Observational Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 15, 2025
Registry last updated
Jun 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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