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Completed

NCT Number: NCT05238805

Double Pet Project : A Comparison Between 11C-Acetate and 11C-acetoacetate Heart and Kidney Uptake

The objective of this study is to make a comparison between 11C-acetate and 11C-Acetoacetate heart and kidney metabolism

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Key information

Conditions

Ketoses, Metabolic Acid-Base Imbalance Acidosis Ketosis Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Research Center on Aging

Sherbrooke, Quebec, J1H 4C4, Canada

About this study

Healthy people will have two positron emission tomography scan to perform. One, with a 11C-Acetate Tracer and the other with 11C-Acetoacetate. The results will allow to determine if both tracers are used in a similar way but the organs and see if the investigators can use the already validated analyse method for acetate to make acetoacetate analysis

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged between 18 and 55
  • BMI between 18,5 and 28
  • Healthy
  • Normal value for blood pressure

Exclusion criteria

  • Taking drugs that could influence metabolism
  • Diabetes or prediabetes
  • Pregnancy or lactation
  • Participation in a intensive sport program
  • Being on a ketogenic diet
  • Any clinical abnomally in prescreen blood sample

Treatment and study plan

Observational heart and kidney on siemens TEP scan

Radiation

Same as arm description

Primary outcomes

  1. Mean in left ventricule myocradial blood flow

    Time frame: 30 minutes

    Heart acetate metabolism measured by TEP scan

  2. Mean in left ventricule myocardial blood flow

    Time frame: 30 minutes

    Heart acetoacetate metabolism measured by TEP scan

  3. Mean in Kidney acetate uptake

    Time frame: 30 minutes

    Kidney acetate uptake measured by TEP scan

  4. Mean in Kidney acetoacetate uptake

    Time frame: 30 minutes

    Kidney acetoacetate uptake measured by TEP scan.

Sponsors and collaborators

Lead sponsor

Université de Sherbrooke

Other

Collaborators

  • Nestlé Health Science Spain

Registry information

Official study title

Double Pet Project : A Comparison Between 11C-Acetate and 11C-acetoacetate Heart and

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Feb 14, 2022
Registry last updated
Jan 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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