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Completed

NCT Number: NCT00993902

Double and Single Intrauterine Insemination In Controlled Ovarian Stimulation (COH) Cycles With Multifollicular Development

Our hypothesis is double insemination will improve pregnancy rates in coh cycles with more than one dominant follicles (>16mm).

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

20 year–37 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Baskent University Medical Faculty Obstetric and Gynecelogy Department, Infertility and IVF unit

Adana, 01120, Turkey (Türkiye)

About this study

Metaanalysis for the effects of double IUI demonstrates that effects of this procedure is not different from single IUI. It is known that nearly 25% of coh cycles is evident by monofollicular development.For this reason it is possible that this monofollicular cycles in the studies could decrease the effects of double IUI.

Inclusion criteria

  • Patients with unexplained infertility or mild male factor infertility whom admitted to the COH+IUI programme in our infertility unit.
  • Female age <37 years old.
  • Baseline FSH <12 mIU/L
  • Total antral follicle count>6
  • During the first three cycles of COH+IUI
  • Minimum 2 follicles >16 mm at the day of HCG.

Primary outcome:

Ongoing pregnancy rates

Secondary outcomes:

The effects of different coh regimens (CC,FSH,CC+FSH)on the outcomes.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Unexplained and mild male factor infertile patients
  • Minimum 2 follicles >16 mm at the day of HCG
  • First 3 cycles

Exclusion criteria

  • Basal FSH >12 mIU/L
  • Total antral follicle count<6
  • Severe male factor infertility

Treatment and study plan

Intrauterine insemination (single)

Procedure

Single IUI after 36-38 hours of HCG

Other names: Group I

Double intrauterine insemination

Procedure

Double insemination after 18 and 40 hours of HCG administration.

Other names: Grup II

Primary outcomes

  1. ongoing pregnancy rates

    Time frame: pregnancy >12 weeks of gestation

Secondary outcomes

  1. The effects of different coh regimens on outcomes

    Time frame: 14 days after IUI procedure

Sponsors and collaborators

Lead sponsor

Baskent University

Other

Registry information

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Oct 14, 2009
Registry last updated
Oct 14, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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