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Completed

NCT Number: NCT01218633

Dose-response Study of Exendin-9,39 on Glucose Metabolism

Multiple studies have examined the effect of endogenous GLP-1 secretions by using a competitive antagonist of GLP-1 - Exendin-9,39 - infused at rates of 300pmol/kg/min. However, the presence of an effect does not necessarily imply that this effect is due to the blockade of the endogenous GLP-1 actions at the receptor. It is possible that the supraphysiologic concentrations of Exendin may have effects of its own. To examine the effect of Exendin on glucose metabolism the investigators propose a dose-response study to determine whether the compound has effects in a dose-dependent fashion.

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Key information

Conditions

Pancreatic Effects of 9,39-Exendin and 9,36-GLP-1

Age range

20 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Healthy Not on any medication other than thyroid hormone replacement or OCP No history of diabetes No prior upper GI surgery

Treatment and study plan

Saline infusion

Drug

saline infused at 30ml/hour

GLP-1-9,36 infusion

Drug

infused @ 1.2pmol/kg/min

Exendin-9,39 at low dose

Drug

infused at 30pmol/kg/min

Exendin-9,39 at high dose

Drug

infused @ 300pmol/kg/min

Primary outcomes

  1. Insulin Secretion

    Time frame: over 360 minutes of study

Secondary outcomes

  1. glucagon secretion

    Time frame: over 360 minutes of study

Sponsors and collaborators

Lead sponsor

Adrian Vella

Other

Registry information

Official study title

A Dose-response Study of the Effects of Exendin-9,39 on Glucose Metabolism, Glucagon and Insulin Secretion and on Insulin Action.

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Oct 11, 2010
Registry last updated
Jan 23, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.