Dose-response Effects of Soybean Oil in Salad Dressing on Carotenoid/Fat-soluble Vitamin Bioavailability in Salad Vegetables

The objectives will be to evaluate the dose-response between the amount of soybean oil in salad dressing and the absorption of: 1) carotenoids, phylloquinone, and tocopherols in salad vegetables; 2) retinyl palmitate formed from the provitamin A carotenoids, alpha- and beta-carotene.

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Key information

Conditions

Biological Availability

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

General good health as determined by interview, blood biochemistry profile, complete blood count, and plasma lipid and lipoprotein profile

Exclusion criteria

Cigarette smoking, frequent alcohol consumption
Use of vitamin/mineral supplements
Lactose intolerance
Known food allergies
Body mass index (BMI) 30 or higher
Eating disorder or restrained eating
Vegetarianism
Hyperlipidemia
Current or planned pregnancy
Use of hormonal contraceptives (affects chylomicron clearance); use of plant sterols or medications known to affect lipid metabolism

Treatment and study plan

Soybean oil in salad dressing

Other

Primary outcomes

Area under the curve for carotenoids, phylloquinone, tocopherols, and retinyl palmitate in the plasma chylomicron fraction

Time frame: 0-9.5 hours postprandially

Sponsors and collaborators

Lead sponsor

Iowa State University

Other

Registry information

Important dates

Study start: 2009
Primary completion: 2009
Study completion: 2016
First posted: Aug 16, 2016
Registry last updated: Aug 18, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed