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Completed

NCT Number: NCT00606242

Dose Response Effects of Inhaled Fluticasone on Airway Effects of Hypertonic-saline in Asthma

This study investigates the effect of a inhaled corticosteroid (fluticasone or "Flovent") on airway narrowing induced by hypertonic saline (salty water). The study hypothesis is that fluticasone will be more effective in preventing saline-induced airway narrowing than methacholine-induced narrowing.

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Key information

Conditions

Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University of California, San Francisco

San Francisco, California, 94143, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of asthma

Exclusion criteria

  • Habitual cigarette smoking

Treatment and study plan

Fluticasone

Drug

Inhaled Fluticasone, either 100 or 1000 mcg per day

Other names: Flovent

Primary outcomes

  1. FEV1

    Time frame: Measured every 2 weeks

Secondary outcomes

  1. PC20 methacholine

    Time frame: Measured every 2 weeks

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Collaborators

  • GlaxoSmithKline
  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Official study title

A Randomized Double Blind Study of the Dose Response Effects of Fluticasone Propionate on Hypertonic-saline Induced Bronchoconstriction in Asthmatic Subjects

Acronym: FluSAL

Important dates

Study start
2000
Primary completion
2002
Study completion
2007
First posted
Feb 1, 2008
Registry last updated
Mar 10, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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