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OpenTrials
Completed

NCT Number: NCT01007760

Dose-dependent Effects of Second-hand Smoke on Vascular Function

The purpose of this study is to determine the vascular effects of brief second-hand smoke exposure on normal healthy individuals.

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Key information

Conditions

Cardiovascular Disease Arterial Occlusive Diseases Arteriosclerosis Atherosclerosis Cardiovascular Diseases Vascular Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UCSF San Francisco General Hospital

San Francisco, California, 94110, United States

About this study

Second-hand smoke remains a significant public health threat. Despite evidence to suggest that secondhand smoke contributes to adverse cardiovascular outcomes, little is known about the dose-dependent vascular effects of brief secondhand smoke exposure at low doses commonly encountered in the community. This study will investigate the acute vascular effects and dose-dependent biological mechanisms of secondhand smoke on endothelial function and oxidative stress.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy non-smoking adults

Exclusion criteria

  • Reported Active Smoking
  • History of diabetes, hypertension, chronic respiratory disease, coronary artery disease, prior myocardial infarction or heart failure
  • Pregnancy or breastfeeding
  • Current use of prescription drugs within 14 days of trial
  • Reported significant passive smoke exposure or elevated cotinine levels

Treatment and study plan

Respirable suspended particles (RSP) PM 2.5 dose of second-hand smoke

Other

acute one time exposure

Primary outcomes

  1. Brachial Artery Flow-mediated dilation (FMD)

    Time frame: Same day - before/after exposure

Secondary outcomes

  1. Plasma measurement of asymmetric dimethylarginine (ADMA) and Nitrotyrosine levels

    Time frame: Same day - before/after exposure

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Registry information

Official study title

Dose-dependent Biological Mechanisms of Second-hand Smoke on Endothelial Function and Oxidative Stress

Important dates

Study start
2009
Primary completion
2010
Study completion
2011
First posted
Nov 4, 2009
Registry last updated
Jul 19, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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