Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia

Fentanyl is expected to suppress tracheal tube-induced cough during emergence from general anaesthesia through binding to its receptors in the brainstem. However, it has not been proven if fentanyl has a complication-free, dose-dependent effect on cough suppression during emergence from sevoflurane anaesthesia. The purpose of this study is to evaluate the relationship between fentanyl doses and cough suppression during emergence from sevoflurane anaesthesia.

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Key information

Conditions

Thyroid Neoplasm Endocrine Gland Neoplasms Endocrine System Diseases Head and Neck Neoplasms Neoplasms Neoplasms by Site Thyroid Diseases Thyroid Neoplasms

Age range

20 year–59 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Severance Hospital

Seoul, 120-752, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

the patients undergoing general anaesthesia for elective thyroidectomy due to thyroid neoplasm.
ASA I-II.
20-59 years old.
female only.

Exclusion criteria

signs of difficult intubation.
risks for perioperative pulmonary aspiration.
history of chronic respiratory disease.
recent upper respiratory track infection.
previous and recent smoking history

Treatment and study plan

Fentanyl Citrate

Drug

According to the enrolled group, certain dose of fentanyl is intravenously administered by bolus just after sevoflurane discontinuation.

Saline

Drug

According to the enrolled group, certain dose of saline is intravenously administered by bolus just after sevoflurane discontinuation.

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start: 2010
Primary completion: 2010
Study completion: 2010
First posted: Mar 4, 2011
Registry last updated: Mar 4, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed