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NCT Number: NCT01961427

Dose and Response of Dietary Nitrate in Healthy and Active Men

It was shown by some researchers that dietary nitrate such as beet root juice can lower oxygen consumption in men and act as a performance enhancing supplement.

It was not shown, what the optimal dosage is and if there is any difference in oxygen consumption comparing beet root juice and inorganic nitrate.

Therefore, the aim of the study is to conduct a study ingesting different sodium nitrate and beet root juice dosages. We would measure nitrate and nitrite concentrations in the blood at different time points and the subjects have to perform an exercise test measuring oxygen consumption 3 hours after the ingestion of nitrate.

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Key information

Conditions

Healthy

Age range

18 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Swiss Paraplegic Centre

Nottwil, Canton of Lucerne, 6207, Switzerland

About this study

  • The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Every hour a blood withdrawal is taken to measure nitrate and nitrite concentration in the blood.
  • The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Three hours after the intake of the supplement the subjects have to perform an exercise test on a bicycle. They have to cycle 5 min at 50% of maximal oxygen consumption and 8min at 80% of maximal oxygen consumption separated by a 5min break. Oxygen consumption would be measured during the whole exercise test. Blood withdrawal is taken before the ingestion, after 3 hours and after the test.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 18 to 45
  • healthy active men
  • non-smoking

Exclusion criteria

  • medication intake during study phase

Treatment and study plan

Sodium nitrate

Dietary Supplement

Ingestion of 3mmol, 6mmol and 12mmol sodium nitrate

Other names: Inorganic nitrate

Beetroot juice

Dietary Supplement

concentrated beetroot juice (dosage 3mmol, 6mmol and 12mmol)

Other names: Biotta beetroot juice shot

Primary outcomes

  1. oxygen consumption

    Time frame: 30min

    Oxygen consumption during exercise protocol

Secondary outcomes

  1. Blood pressure

    Time frame: 6 hours

    every hour, blood pressure is measured.

  2. oxygen saturation

    Time frame: 6 hours

    every hour oxygen saturation is measured.

  3. Rating of perceived exertion (RPE)

    Time frame: during the 7 weeks of study phase

    RPE is measured after the low-intensity exercise performance and after the submaximal exercise performance.

  4. Heart rate

    Time frame: during the 7 weeks of study phase

    Heart rate is measured before the ingestion, before the exercise test and during the exercise test. resting heart rate is additionally measured every hours after the intake of dietary/inorganic nitrate.

  5. Nitrate and nitrite concentration

    Time frame: 6 hours

    every hour for the six hours after the ingestion of dietary/inorganic nitrate, nitrate and nitrite concentration in the blood is analyzed.

Sponsors and collaborators

Lead sponsor

Swiss Paraplegic Research, Nottwil

Network

Collaborators

  • University of Zurich

Registry information

Official study title

Dose and Response of Dietary and Inorganic Nitrate in Healthy and Active Men

Important dates

Study start
2013
Primary completion
2016
Study completion
2016
First posted
Oct 11, 2013
Registry last updated
Nov 21, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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