Dosage Calculation for Vitamin D Treatment

Severe vitamin D deficiency can be treated with oral loading doses of cholecalciferol. Our objective was to determine how to calculate the quantity of cholecalciferol needed for supplementation by single algorithm, usable on a patient-to-patient basis.

We've conducted two studies. Study 1 was done retroactively and included 88 patients treated for low vitamin D, 60 of those with a loading dose. The second study included 29 patients and aimed to test the validity of an algorithm based on data from study 1, which included patient BMI. Both studies used oral loading doses and daily supplementation of cholecalciferol.

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Key information

Conditions

Deficiency, Vitamin D Avitaminosis Body Weight Deficiency Diseases Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Vitamin D Deficiency

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

severe hypovitaminosis D (25OH-vit.D <25 nmol/L)

Exclusion criteria

Malabsorption
Renal disease
Other treatment with vitamin D related products
Patients with a recent travel history with suspected increased sun exposure

Treatment and study plan

Cholecalciferol

Drug

Other names: Dekristol capsules of 20.000 IU pr. capsule

Primary outcomes

Change in baseline value of [25-OH-vitamin-D]

Time frame: 1 week, 3 weeks and 3 months

Sponsors and collaborators

Lead sponsor

Bispebjerg Hospital

Other

Registry information

Official study title

The Effect of Oral Loading Doses of Cholecalciferol on the Serum Concentration of 25-OH-vitamin-D

Important dates

Study start: 2012
Primary completion: 2013
Study completion: 2013
First posted: Jul 10, 2014
Registry last updated: Jul 10, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed