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OpenTrials
Completed

NCT Number: NCT06658392

Domain-general and Domain-specific Contributions to the Development of Numerical Cognition

Exploring the non-symbolic and symbolic arithmetic competencies in two groups of children (5-, and 7-year-olds). Additionally, we explored the relationship with domain-general factors such as inhibition and attention. Recorded fMRI.

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Key information

Conditions

Age range

5 year–7 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre Hospitalier Sainte-Anne

Paris, 75014, France

About this study

Using T2*-weighted eip imaging, we measured BOLD response in two cohorts of healthy children while they were doing different cognitive tasks in the scanner. These tasks included solving non-symbolic (i.e. sets of elements) and symbolic (i.e. Arabic digits) addition and subtraction problems, a color control task, an attentional task measuring different facets of spatial attention, and a task measuring inhibition. We also recorded a high-resolution anatomical scan of the brain.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • school enrollment
  • French as mother tongue
  • right-handed
  • normal medical, neurological and neuroradiological examinations - parents affiliated to a social security scheme

Exclusion criteria

  • not within age range
  • monocygotic twins
  • - contraindications to an MRI examination (neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic ocular or cerebral foreign bodies close to nerve structures, metal prostheses, patient agitation: uncooperative or agitated patients, claustrophobic subjects, ventriculoperitoneal neurosurgical shunt valves, dental apparatus, etc.).
  • sudden onset of cognitive problems that could indicate a stroke; a history of head trauma with loss of consciousness lasting more than 1 hour, or encephalitis; - a chronic neurological, psychiatric, endocrine, hepatic or infectious condition
  • a history of major illness (diabetes, chronic lung disease, severe cardiac, metabolic, hematological, endocrinological or immunological disorders, cancer); - medication likely to interfere with brain imaging measurements
  • color blindness or uncorrected visual disorders
  • inability to take part in the study for geographical or psychiatric reasons
  • presence of pervasive developmental and/or acquisition disorders identified by parents or legal guardians and/or teachers
  • cerebral palsy
  • impaired fine motor skills
  • parents or legal guardians not affiliated to a social security scheme
  • unaccompanied by parent(s) or legal guardian(s) during visits.
  • tattoo not compatible with MRI
  • children and parents under legal protection

Treatment and study plan

cognitive tasks

Other

no intervention in a medical sense, only observing changes of BOLD signal during different experimental conditions in cognitive tasks (arithmetic, attention, inhibition)

Primary outcomes

  1. BOLD response

    Time frame: BOLD response recorded during fMRI session

    changes of BOLD response under different experimental conditions (non-symbolic arithmetic; symbolic arithmetic; inhibition; attention)

  2. BOLD response

    Time frame: during fMRI session

    changes of BOLD response in experimental conditions

Sponsors and collaborators

Lead sponsor

Centre Hospitalier St Anne

Other

Registry information

Acronym: CFDDCN

Important dates

Study start
2021
Primary completion
2024
Study completion
2024
First posted
Oct 26, 2024
Registry last updated
Oct 26, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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