Does Sourdough Fermentation Improve Iron Uptake From Whole Grain Rye Bread?

Iron deficiency anaemia is a major problem for women worldwide. Cereal foods are a major source of iron, but much of this is not bioavailability due to it being bound by the high amounts of phytate present in cereals. Destruction of phytate by the phytase enzyme can release iron and increase its bioavailability. In a human cell model of iron uptake, sourdough fermentation, which included activation of phytase, the enzyme that breaks down phyate, led to improved iron bioavailability. This clinical trial will attempt to demonstrate that this concept also works in humans

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Key information

Conditions

Iron Bioavailability Anaemia Anemia Hematologic Diseases Hemic and Lymphatic Diseases

Age range

18 year–50 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy women under 50 years old

Exclusion criteria

Pregnancy or breast feeding
Use of mineral or other dietary supplements
Use of medical or recreational drugs
Donation of blood within the previous 3 months

Treatment and study plan

Whole grain rye bread

Other

Whole grain rye bread baked without sourdough fermentation (normal yeast-based fermentation)

Whole grain sourdough rye bread

Other

Whole grain rye bread fermented with sourdough culture before baking

Primary outcomes

Serum ferritin

Time frame: 12 week values corrected for baseline
Serum transferrin receptor

Time frame: 12 week values corrected for baseline
Haemoglobin

Time frame: 12 week values corrected for baseline

Sponsors and collaborators

Lead sponsor

Chalmers University of Technology

Other

Collaborators

Sahlgrenska University Hospital

Registry information

Important dates

Study start: 2010
Primary completion: 2013
Study completion: 2015
First posted: Jun 4, 2015
Registry last updated: Mar 15, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed