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Completed

NCT Number: NCT04311996

Does Social Buffering Continue to be Effective Over the Peripubertal Period When Friends Share the Stressor Experience?

The purpose of this experiment is to determine whether social buffering by friends of stress physiology remains effective later in puberty when friends share the load versus when they provide support but are not undergoing the stressor with the target child. There are four conditions: (1) Friend and Target both undergo the stressor, (2) Friend provides support but does not undergo the stressor, (3) Unfamiliar Peer and Target undergo the stressor, and (4) Alone (no partner).

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Key information

Age range

11 year–14 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

About this study

Adolescents experience social evaluation stress frequently. However, it is likely that often they are not alone, but with friends who are also going through the same experience. Thus, it is possible that under these conditions, social buffering by friends does not wane over the peripubertal period. Participants will be assigned to social conditions while engaging in an evaluative stressor task.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • sufficient vision, hearing, and language skills to provide verbal and written assent
  • ability to see and read stimuli presented on the computer screen
  • ability to hear verbal instructions provided by the experimenter and judges

Exclusion criteria

  • premature birth (less than 37 weeks)
  • congenital and/or chromosomal disorders (e.g. cerebral palsy, FAS, mental retardation, Turner Syndrome, Down Syndrome, Fragile X)
  • Autism Spectrum Disorders
  • history of serious medical illness (e.g., cancer, organ transplant)
  • serious psychiatric illness
  • systemic glucocorticoids or beta-adrenergic medication use

Treatment and study plan

Friend and target

Other

random assignment to Friend and Target Both condition

Friend support

Other

random assignment to Friend Provides Support condition

unfamiliar peer and target

Other

random assignment to Unfamiliar Peer and Target condition

alone

Other

random assignment to Alone condition

Primary outcomes

  1. Cortisol AUCi

    Time frame: 2 hours

    Cortisol response to the TSST, measured as Area Under the Curve, increase from baseline. 7 Samples were taken during the course of the assessment, at (1) arrival for training purposes; (2) after the calming video, 30 minutes after arrival; (3) after 5 minutes of speech preparation; (4) after 10+minutes of speech and math performance; (5) 15 minutes after sample 4; (6) 10 minutes after sample 5; (7) 10 minutes after sample 6. Area under the curve at intercept (AUCi) is calculated using samples 2-7 with sample 2 as the intercept.

  2. sAA AUCi

    Time frame: 2 hours

    Salivary Alpha Amylase response to the TSST, measured as Area Under the Curve, increase from baseline. 7 Samples were taken during the course of the assessment, at (1) arrival for training purposes; (2) after the calming video, 30 minutes after arrival; (3) after 5 minutes of speech preparation; (4) after 10+minutes of speech and math performance; (5) 15 minutes after sample 4; (6) 10 minutes after sample 5; (7) 10 minutes after sample 6. Of those, samples (2, 4, 5) are assayed for salivary alpha amylase (sAA) in micrograms per milliliter. Area under the curve at intercept (AUCi) is calculated using samples 2, 4, 5 with sample 2 as the intercept.

Secondary outcomes

  1. Self Report of Stress

    Time frame: 2 hours

    Self-report of stress using a Likert-type scale with 5 levels of stress felt: (1) Not At All, (2) A Little, (3) Some, (4) A Lot, (5) A Whole Lot. Level of stress was reported for at these points during the assessment: (1) How stressed did you feel when you first connected on the video call and saw the experimenter?, (2) How stressful was the period of time before we started the video?, (3) How stressful did you feel while watching the video?, (4) How stressful was the period of time when you were preparing your speech and thinking about what to say?, (5) How stressful was giving the speech?, (6) How stressful was the math portion?, (7) How stressed do you feel now, after the speech and math portions are done? Self reported stress was computed as the mean of items (4, 5, 6) - item 1.

Other outcomes

  1. Hours Since Awakening. Potential Covariate

    Time frame: day of testing session

    Participants report the number of hours between waking up on the day of assessment and the start of the TSST test.

    This is only a potential covariate for cortisol, which follows a circadian rhythm.

  2. Pretax Family Income. Potential Covariate

    Time frame: calendar year previous to TSST session

    Parents report on gross family income on an 11-point ordinal scale: (1) Less than $15,000, (2) $15,001 to $25,000, (3) $25,001 to $35,000, (4) $35,001 to $50,000, (5) $50,001 to $75,000, (6) $75,001 to $100,000, (7) $100,001 to $125,000, (8) $125,001 to $150,000, (9) $150,001 to $175,000, (10) $175,001 to 200,000, (11) $200,001 or more

  3. Parental Average Education Level. Potential Covariate

    Time frame: lifetime

    Parents report education level for both parents on a 6-point ordinal scale: (1) Less than high school degree, (2) High school or GED, (3) Associate degree, college academia program, (4) Bachelor's degree, (5) Master's degree, (6) Professional and/or Doctorate degree. Average of parents' education is calculated and reported.

  4. Number of Adults in the Home. Potential Covariate

    Time frame: day of TSST session

    Parents report on how many adults are living in the home.

  5. Caffeine or Nicotine Use. Potential Covariate

    Time frame: 1-2 hours prior to TSST session

    Youth report on whether they consumed caffeine or nicotine in the 1-2 hours prior to the TSST assessment. Coded as no=0, yes=1. Used as a potential covariate for heart rate and neuroendocrine measures.

  6. Granger Score. Potential Covariate

    Time frame: day of 2 hour TSST session

    The Granger score (ordinal, modeled continuously) is a score based on work by Doug Granger of medications that can affect activity of the HPA axis, weighted by significance of potential impact (Granger, Hibel, Fortunato, & Kapelewski, 2009). Each medication taken is given a score of 0, 1, or 2, and all medication scores for a participant is summed, resulting in scores from 0 to infinity. Lower scores are less likely to influence cortisol. Potential Covariate

  7. Quality of Relationship With Primary Parent, BSV Positive Attachment Scale. Potential Covariate

    Time frame: 2 hour TSST session

    Network of Relationships Inventory (NRI) reported by youth for their primary parent on how much they experience various emotions or incidents (e.g. How much free time do you spend with this person?), reported on a 5-point scale: (1) Little or None, (2) Somewhat, (3) Very Much, (4) Extremely Much, (5) The Most. Mean scores calculated from all positive attachment items, range 1-5. Potential Covariate. This self report reflects the general current state of the relationship, without a specific timeframe, and was obtained during the TSST session.

  8. Quality of Relationship With Close Friend, BSV Positive Attachment Scale. Potential Covariate

    Time frame: 2 hour TSST session

    Network of Relationships Inventory (NRI) reported by youth for their close friend on how much they experience various emotions or incidents (e.g. How much free time do you spend with this person?), reported on a 5-point scale: (1) Little or None, (2) Somewhat, (3) Very Much, (4) Extremely Much, (5) The Most. Mean scores calculated from all positive attachment items, ranging 1-5. Potential Covariate. This self report reflects the general current state of the relationship, without a specific timeframe, and was obtained during the TSST session.

  9. Peer Acceptance/Rejection. Potential Covariate

    Time frame: 2 hour TSST session

    Scale on the MacArthur Health and Behavior Questionnaire, 5pt scale (1-5), high scores indicate peer acceptance. This report reflects the general current state of the youth, without a specific timeframe, and was obtained during the TSST session.

  10. Behavioral Inhibition. Potential Covariate

    Time frame: 2 hour TSST session

    Scale on the MacArthur Health and Behavior Questionnaire, 3pt scale (0,1,2), high scores indicate inhibition. This report reflects the general current state of the youth, without a specific timeframe, and was obtained during the TSST session.

  11. Internalizing Symptoms. Potential Covariate

    Time frame: 2 hour TSST session

    Higher order measure from the MacArthur Health and Behavior Questionnaire, 3pt scale (0,1,2), high scores indicate Internalizing. This report reflects the general current state of the youth, without a specific timeframe, and was obtained during the TSST session.

  12. Externalizing Symptoms. Potential Covariate

    Time frame: 2 hour TSST session

    Higher order measure from the MacArthur Health and Behavior Questionnaire, 3pt scale (0,1,2), high scores indicate externalizing. This report reflects the general current state of the youth, without a specific timeframe, and was obtained during the TSST session.

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Mar 17, 2020
Registry last updated
Feb 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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