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NCT Number: NCT07200531

Does Psychotherapy Change the Gut Microbiome in Women of Child-bearing Age?

The goal of this clinical trial is to learn if group therapy for six weeks changes the gut microbiome in women. The main questions it aims to answer are:

Is chronic stress associated with the gut microbiome? Will six weeks of therapy change the gut microbiota?

Participants will:

Answer questionnaires about chronic stress Mail a stool sample before and after the intervention. Participate in a 1-hour group therapy session over the course of six weeks.

Recruiting

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Key information

Conditions

Chronic Stress

Age range

19 year–54 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

Location status: Recruiting

Location contact

Tiffany Moore

CONTACT

[email protected]

402-559-6613

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women over the age of 19 and less than 54. Able to understand/read English

Exclusion criteria

  • Pregnant women and breast-feeding women Women who are actively participating in psychotherapy on a regular basis

Treatment and study plan

Psychotherapy

Behavioral

6-week psychotherapy group intervention

Primary outcomes

  1. Depression, Anxiety, and Stress Scales

    Time frame: 6 weeks

    Self-report mood disorder questionnaire

  2. Perceived Stress

    Time frame: 6 weeks

    self-report questionnaire of perceived stress

Study contacts

Contact information is provided by the study sponsor or research team.

Ashley J Blount, PhD

CONTACT

[email protected]

4025596613

Tiffany A Moore, PhD, RN

CONTACT

[email protected]

4025596613

Sponsors and collaborators

Lead sponsor

University of Nebraska

Other

Registry information

Official study title

Impact of Biopsychosocial Psychotherapy Intervention on Maternal Life-Course Trauma and the Gut Microbiome

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Oct 1, 2025
Registry last updated
Mar 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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