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Completed

NCT Number: NCT05295095

Does Positive Pressure Extubation Reduce Postoperative Desaturation?

Single-center, prospective, controlled, parallel, randomized, single-blind study comparing the conventional extubation technique to two positive pressure extubation techniques on postoperative desaturations

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Key information

Conditions

Extubation Lung Ultrasound Score Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hop Claude Huriez Chu Lille

Lille, 59037, France

About this study

Study realise on university hospital on Lille in France. Patients inclusion is prospective and randomised in three groups. First group : extubation is realised with aspiration in tracheal tube during removal tube Second group : extubation is realised without aspiration but with APL valve set to 20cmH20 Third group : extubation is realised without aspiration but with ventilator parameters were set for PSV mode (inspiratory pressure of 10cmH2O and PEEP identical to that administered in the operating room

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Visceral or urological surgery
  • Scheduled surgery
  • Surgical or patient requirement: placement of an arterial catheter
  • Supine position
  • Post-surgical extubation scheduled in the operating room
  • Minimum age of 18 years
  • Informed and signed consent

Exclusion criteria

  • Severe obesity (BMI over 35kg/m2)
  • pregnant woman
  • Acute or chronic preoperative respiratory pathology.
  • Sleep apnea syndrome
  • Inability to receive informed information (does not speak, read or understand French)
  • Patient under guardianship or curatorship
  • Lack of social security coverage
  • History of intubation or criteria for difficult intubation or ventilation.

Treatment and study plan

positive pressure during extubation procedure

Procedure

positive pressure during extubation procedure

Primary outcomes

  1. desaturations during extubation

    Time frame: 1 minute after extubation

    saturation <92%

Secondary outcomes

  1. desaturation postoperatory

    Time frame: 5 and 30 minutes after extubation

    saturation<92%

  2. hypoxemia post operatory

    Time frame: 1 and 30 minutes after extubation

    PaO2 <60mmHg

  3. atelectasis

    Time frame: 30 minutes after extubation

    Lung ultrasound score (LUS); min = 0, max = 32, higher scores mean is worse outcome

  4. awakening time

    Time frame: through extubation completion, an average 2 minutes

    time in seconds

  5. use of oxygen

    Time frame: day 7

    days Numbers of oxygen therapy, kinesiotherapy, non invasive ventilation

  6. post operative complications

    Time frame: day 7 and day 28

    Clavien Dindo Score; min = grade I, max = grade V; higher scores mean is worse outcome

  7. feasibility and acceptance of both techniques pressure positive extubation

    Time frame: 15 minutes after extubation

    questionnaire, min = 4, max =20, higher scores mean is worse outcome

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

The Value of Positive Pressure Extubation in Reducing Postoperative Desaturation Episodes in Adults Undergoing Abdominal Surgery

Acronym: EXTUBPOS

Important dates

Study start
2022
Primary completion
2026
Study completion
2026
First posted
Mar 24, 2022
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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