Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block Has a System Analgesic Effect?

the investigators aim is to investigate and explore the effect 10 mg morphine added to local anesthetics in serratus anterior plane block for post mastectomy pain management after modified radical mastectomy in patients with breast cancer with assessment of its serum level if it will be absorbed systemically or not?

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Key information

Conditions

Postoperative Complications Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

South Egypt Cancer Instuite

Asyut, 171516, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(ASA) class I-II
body weight of 50 - 90 kg

Exclusion criteria

a history of bleeding diathesis,
relevant drug allergy, opioid dependence,
sepsis, prior surgery in the supraclavicular, infraclavicular or axillary regions, alcohol or drug abuse , patients with advanced cardiovascular disease

Treatment and study plan

Morphine sulfate

Drug

Other names: morphine

Bupivacaine Hydrochloride

Drug

Other names: marcaine

Primary outcomes

serum morphine level after local injection

Time frame: 24 hours

concentration of serum morphine in ng/ml after local injection

Sponsors and collaborators

Lead sponsor

Fatma Adel El sherif,MD

Other

Registry information

Official study title

Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block for Post Mastectomy Pain Has a System Analgesic Effect? A Clinical and Pharmacokinetics Study

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2018
First posted: Nov 11, 2016
Registry last updated: Jan 22, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed