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OpenTrials
Completed

NCT Number: NCT05634083

Does Indoxyl Sulfate Have a Role in Uremic Pruritus?

Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe itching. The pathogenesis of renal pruritus is multifactorial. Triggering factors may include uremia-related abnormalities, accumulation of uremic toxins, systemic inflammation and cutaneous xerosis. Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan accumulating in patients with end-stage renal disease.

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Key information

Conditions

Pruritus Pathological Conditions, Signs and Symptoms Signs and Symptoms Skin Diseases Skin Manifestations Skin and Connective Tissue Diseases

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine, Benha University, Al Qalyūbīyah, Benha, Egypt

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About this study

Patients with end-stage renal disease undergoing hemodialysis complaining of itching not related to other cause than renal failure will take activated charcoal with foods and serum level of indoxyl sulphate will be studied

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with end-stage renal failure with itching undergoing regular hemodialysis

Exclusion criteria

Patients with other causes of itching as psoriasis, atopic dermatitis, scabies, and lichen planus

Treatment and study plan

Uremic pateints with itching

Dietary Supplement

Activated charcoal

Primary outcomes

  1. Severity of itching

    Time frame: Two months

    Change of severity of itching by The Visual Analogue Scale score

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

Does Indoxyl Sulfate Have a Role in Uremic Pruritus? A Laboratory and Interventional Study.

Important dates

Study start
2022
Primary completion
2022
Study completion
2023
First posted
Dec 1, 2022
Registry last updated
Feb 8, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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