Does APOE-e4 Predict Delirium and Cognitive Dysfunction After Surgery?

Patients with the APOE-ε4 genotype are at increased risk of both vascular dementia and peripheral vascular disease. Patients undergoing major vascular surgery are at particularly high risk of delirium and other, more subtle, changes in cognitive function following surgery. The hypothesis of this trial is that the APOE-ε4 genotype is associated with both delirium and postoperative cognitive dysfunction (POCD).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Delirium Cognition Disorders Cognitive Dysfunction Confusion Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Cognitive Complications Postoperative Cognitive Dysfunction Postoperative Complications Signs and Symptoms

Age range

60 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The Ottawa Hospital - Civic Campus

Ottawa, Ontario, K1Y 4E9, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 60 or greater
Open repair of the abdominal aorta

Exclusion criteria

refusal;
planned endovascular repair;
emergency surgery;
previous diagnosis of dementia, Parkinson's disease, or psychiatric illness;
active alcohol or substance abuse; and
physical inability to complete neuropsychometric testing.

Treatment and study plan

Primary outcomes

Delirium as assessed by the Confusion Assessment Method

Time frame: 7 days postoperatively

Secondary outcomes

POCD as assessed by a battery of 9 neuropsychometric tests

Time frame: 7 days postoperatively
POCD as assessed by a battery of 9 neuropsychometric tests

Time frame: 3 months postoperatively

Sponsors and collaborators

Lead sponsor

Ottawa Hospital Research Institute

Other

Collaborators

Canadian Anesthesiologists' Society
University of Ottawa

Registry information

Official study title

Does Apolipoprotein E Genotype Predict Delirium and Postoperative Cognitive Dysfunction?

Important dates

Study start: 2005
Primary completion: 2008
Study completion: 2009
First posted: Jun 2, 2009
Registry last updated: Jun 2, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed