Skip to main content
OpenTrials
Completed

NCT Number: NCT05230862

Does a Multi-ingredient Pre-workout Supplement Enhance Cycling Time Trial Performance?

The aim of the present study is to test the effect of ingesting a multi-ingredient pre- exercise supplement containing caffeine, creatine, beta-alanine and L-Citrulline compared to a placebo, on endurance exercise performance.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy Volunteers

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

School of Sport and Health Sciences

Exeter, EX4, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Exclusion criteria

  • Any diagnosed metabolic health condition
  • Pregnant
  • Non-habitual caffeine intake
  • Smoker
  • No endurance training
  • Diagnosed Cardiovascular disease
  • Recent history of musculoskeletal injury
  • Anti-depressant and anti-anxiety medication

Inclusion criteria

  • Age 18-40
  • Healthy
  • Highly trained endurance athletes (V̇O2max: males >55 and females >50 mL⋅kg bm-1⋅min-1)
  • Both males and females are allowed to participate. If females are on the oral contraceptive pill they are to be tested on consecutive weeks. If they are not on the oral contraceptive pill, then female subjects are to be tested every 4 weeks, at the same point of their menstrual cycle.

Treatment and study plan

Ladder Supplement

Dietary Supplement

Caffeine 200mg L-Theanine 200mg L-Citrulline 6g Creatine 5g Beta-Alanine 1.6g Phosphatidylserine 100mg

Placebo

Dietary Supplement

Placebo

Primary outcomes

  1. Exercise Performance

    Time frame: 15 Minitues

    Work done during 15 min time trial (TT)

Secondary outcomes

  1. Alertness

    Time frame: 1 Hour

    Visual analog scale

  2. Motivation

    Time frame: 1 Hour

    Visual analog scale

  3. Rate of perceived exertion

    Time frame: 1 Hour

    Visual analog scale

  4. Gas analysis

    Time frame: 1 Hour

    Analysis of expired gas

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Collaborators

  • OpenFit LLC

Registry information

Official study title

Does a Multi-ingredient Pre-workout Supplement Enhance Cycling Time Trial

Acronym: MIPS

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Feb 9, 2022
Registry last updated
Jul 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.