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Completed

NCT Number: NCT07286851

Do Topical Antibiotics Improve Skin Graft Results?

The goal of this study is to see if putting antibiotic ointment on a skin graft when the surgery is being done helps prevent the skin graft from getting infected after the operation. The study is looking at all skin grafts done in a rural Bangladesh hospital.

The main questions it aims to answer are:

Does the antibiotic lower the number of infections that happen? Does the antibiotic make the overall outcome of the skin graft better? Do patients who get the antibiotic need fewer extra surgeries?

Researchers will compare the outcomes from patients who had skin grafts before the hospital started applying antibiotic ointment to the outcomes of patients after the hospital began applying antibiotic ointment.

Participants who have already had their skin graft treatment completed will have their medical records reviewed by researchers. The outcomes of their treatment will be written down.

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Key information

Conditions

Skin Transplantation Antibiotic Prophylaxis Surgery Wounds and Injuries

Sex eligibility

All sexes

Study type

Observational

Primary location

LAMB Hospital

Parbatipur, Dinajpur, 5250, Bangladesh

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient undergoing a split-thickness skin graft at the hospital where research is conducted

Exclusion criteria

  • Missing or incomplete medical record

Treatment and study plan

Neomycin

Drug

Topical neomycin was applied at the time of split-thickness skin graft surgery.

Primary outcomes

  1. Post-operative infection rate

    Time frame: Measured if present at any time during the patient's initial post-operative hospitalization, which averaged 20 days, from time of operation until time of discharge.

    Whether patients had post-operative infection during their hospitalization, classified as "yes" or "no" as defined by any of the following being present: "post-operative infection" diagnosis written in the patient's medical record, change or increase in antibiotic therapy post-operatively, or the presence of pus documented at the skin graft site.

Secondary outcomes

  1. Skin graft take

    Time frame: Measured at the time of discharge from the patient's initial post-operative hospitalization, which averaged 20 days.

    Percentage of skin graft that remained intact at the time of discharge, as estimated by the treating surgeon and documented in the patient's record.

  2. Need for operative re-intervention

    Time frame: From the time of operation until the end of the study period (up to three years for the earliest skin graft patients).

    Whether patient needed to return to the operating room for additional procedures (such as debridement or repeat skin grafting) for the same wound, classified as "yes" or "no."

  3. Length of stay

    Time frame: Measured at the time of discharge from the patient's initial post-operative hospitalization, which averaged 20 days.

    Number of days spent in the hospital during the initial post-operative period.

  4. Allergic reaction

    Time frame: Measured if present at any time during the patient's initial post-operative hospitalization, which averaged 20 days, from time of operation until time of discharge.

    Whether patient had any allergic reaction to neomycin or any other substance documented - categorized as "yes" or "no," based on the new presentation of rash or pruritis.

Sponsors and collaborators

Lead sponsor

LAMB Project

Other

Registry information

Official study title

Effects of Topical Neomycin on Skin Graft Outcomes in Rural Bangladesh: a Retrospective Cohort Study

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Dec 16, 2025
Registry last updated
Dec 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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