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NCT Number: NCT07165483

Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?

This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.

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Key information

Conditions

Time Dexmedetomidine Fractures, Bone Fractures, Stress Intubation Laryngoscopy Stress Response Wounds and Injuries

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location status: Recruiting

Location contact

Mohammed S Elsharkawy, MD

CONTACT

[email protected]

00201148207870

Saad A Moharam, MD

PRINCIPAL_INVESTIGATOR

About this study

Maintaining hemodynamic stability during surgery is one of the most important tasks because good anesthesia increases the success rate of surgery and improves postoperative prognosis.

Dexmedetomidine, a potent α2-adrenoreceptor agonist, produces not only a sedative-hypnotic effect, but in situations involving cardiac risk, it also produces analgesic effects and an autonomic blocking effect, by acting on a single type of receptor.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age from 18 to 65 years.
  • Both sexes.
  • American Society of Anesthesiology (ASA) physical status I-II.

Exclusion criteria

  • Severe cardiovascular problems.
  • Respiratory disorders.
  • Diabetes.
  • Hypertension.
  • Obesity.
  • Allergic reaction to study drugs.
  • Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists)
  • Medications that affect heart rate (HR) or blood pressure (BP).
  • Pregnant.
  • Currently breast-feeding women.
  • History of sleep apnea.
  • Those for emergency procedures.

Treatment and study plan

Dexmedetomidine

Drug

Patients will receive 0.5µg/kg dexmedetomidine (over 10 min) 20 min before induction of anesthesia then saline (over 10 min) 10 min before induction of anesthesia.

Saline

Drug

Patients will receive saline before induction of anesthesia as a control group.

Primary outcomes

  1. Mean arterial pressure

    Time frame: Till the end of the surgery (Up to 2 hours)

    Mean arterial pressure will be recorded at baseline, before induction, after induction, before intubation, after intubation, at 5 minutes, 10 minutes, 15 minutes, and then every 15 minutes until the end of surgery.

Secondary outcomes

  1. Heart rate

    Time frame: Till the end of the surgery (Up to 2 hours)

    Heart rate will be recorded at baseline, before induction, after induction, before intubation, after intubation, at 5 minutes, 10 minutes, 15 minutes, and then every 15 minutes until the end of surgery.

  2. Need for intraoperative fentanyl

    Time frame: Intraoperatively

    Need for intraoperative fentanyl will be recorded.

  3. Incidence of adverse events

    Time frame: 24 hours postoperatively

    Incidence of adverse events such as bradycardia, hypotension, nausea, vomiting, respiratory depression, or any other complication.

Study contacts

Contact information is provided by the study sponsor or research team.

Mohammed S Elsharkawy, MD

CONTACT

[email protected]

00201148207870

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? A Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 10, 2025
Registry last updated
Sep 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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