Do EEG and Neurocognitive Assessments Correlate With COVID Brainfog Symptoms?

• Screening and Consent - Patients with a diagnosis of COVID-19 will be asked by the research personnel if they are experiencing symptoms of 'brain fog' (confusion, altered memory, headache, trouble concentrating.) Those responding affirmatively will be asked to complete a brief mental status exam (mini MoCA). Those patients scoring 25 or less out of 30 will then move forward to the formal written consent process. We will also recruit 5 control patients who are COVID positive but are not experiencing 'brainfog' symptoms.
• Electroencephalogram (EEG) - We will perform an EEG using a Brainscope device.
• Neurocognitive Assessment (brain function tests) - While the EEG electrodes are still attached, we will perform these assessments that test attention, concentration, reaction time, processing speed, decision making, and executive function. These are called the Structural Injury classifier (SIC) and Concussion Index (CI) assessments that are computed using FDA cleared algorithms for the likelihood of structural brain injury and the likelihood and severity of brain function impairment.
• Full MoCA assessment - After the Brainscope evaluation patients will be asked questions on the paper-based full MoCA cognitive assessment and the score will be recorded.
• Concussion Symptom Inventory (CSI) - Study personnel will ask questions about symptoms using the CSI which is a standardized tool for evaluating injured patients who have concussion.
• Inventory of COVID Symptoms - Research personnel will collect information about COVID symptoms using standardized PROMIS surveys. (Dyspnea severity and Physical Function)
• Demographics - We will collect demographic information that includes age and sex, along with vital signs, pulse oximetry, and supplemental oxygen requirement, physical exam, neurological exam, lab test results, medications given during hospitalization, and results of any imaging done on the head during hospitalization. Standard laboratory results including blood counts, chemistry and biomarkers of inflammation obtained as standard of care will be recorded.
• Follow-up Visit - Participants will return to the clinic for a follow-up visit 45-60 days after discharge from the hospital. At that visit the Brainscope EEG, mental function tests, and symptom surveys will be repeated.

Inclusion criteria

• Current COVID 19 infection
• Experiencing 'brain fog' symptoms (e.g.confusion, mental slowness, unable to concentrate)
• GCS of 14 or 15
• sufficient mental capacity to provide informed consent
• hemodynamically stable
• able to cooperate with EEG collection and neurometric testing
• admitted to a floor bed rather than ICU

Exclusion criteria

• Head or facial trauma
• Any abnormality that would prevent electrodes from being placed on the head
• Known central nervous system (CNS) disease i.e. MS, Parkinson's disease
• Know seizure disorder
• Known dementia
• Metabolic encephalopathy i.e. uremia, hepatic
• Alcohol intoxication to the point they cannot give consent
• Hypoxia that is not corrected to 92% by nasal cannula, or simple face mask
• Chronic alcohol or drug dependence
• Prior cerebrovascular accident (CVA)
• Prior brain surgery
• Known brain mass
• Receiving sedation medications at time of consent
• End stage renal disease (ESRD) on dialysis
• Acute psychosis