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Completed

NCT Number: NCT00898664

DNA Analysis of Tissue Samples From Patients With Head and Neck Cancer

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This laboratory study is looking at DNA in tissue samples from patients with head and neck cancer.

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Key information

Conditions

Head and Neck Cancer Carcinoma Carcinoma, Squamous Cell Head and Neck Neoplasms Mouth Diseases Mouth Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Salivary Gland Diseases Salivary Gland Neoplasms Squamous Cell Carcinoma of Head and Neck Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

OBJECTIVES:

  • Assess common genetic mutations in tumor and germline DNA samples from patients with head and neck squamous cell carcinoma (HNSCC).
  • Search for viral DNAs and relate this information to demographics, tumor characteristics, and patient prognosis.
  • Search for novel viral sequences and cancer-associated gene mutations in young nonsmoking HNSCC patients and in other distinct head and neck cancers.
  • Determine tumor suppressor gene mutations in HNSCC patients and relate this information to gene expression data.
  • Validate gene expression information using independent techniques such as real-time PCR on expressed sequences and immunohistochemistry.

OUTLINE: Genetic mutation analysis and gene expression studies are performed on tissue samples from patients with head and neck squamous cell carcinoma. Techniques used include real time-PCR and immunohistochemistry.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient with head and neck squamous cell carcinoma (HNSCC) enrolled in the Head and Neck Tissue Repository
  • Sufficient biological material collected to perform study tests
  • Historical material available from excess tissues at the Vanderbilt Pathology Department

Exclusion criteria

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified

Treatment and study plan

cytogenetic analysis

Genetic

gene expression analysis

Genetic

mutation analysis

Genetic

polymerase chain reaction

Genetic

immunohistochemistry staining method

Other

laboratory biomarker analysis

Other

Primary outcomes

  1. Assess common genetic mutations in tumor and germline DNA samples

    Time frame: Upon collection of final patient data

  2. Viral DNAs related to demographics, tumor characteristics, and patient prognosis

    Time frame: Upon collection of final patient data

  3. Novel viral sequences and cancer-associated gene mutations in young nonsmoking patients with head and neck squamous cell carcinoma and in other distinct head and neck cancers

    Time frame: Upon collection of final patient data

  4. Tumor suppressor gene mutations related to gene expression data

    Time frame: upon collection of final patient data

  5. Validation of gene expression information using independent techniques such as real-time PCR on expressed sequences and immunohistochemistry

    Time frame: upon collection of final patient data

Sponsors and collaborators

Lead sponsor

Vanderbilt-Ingram Cancer Center

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Official study title

Genetic Analysis of Head and Neck Squamous Cell Carcinoma

Important dates

Study start
2006
Primary completion
2008
Study completion
2008
First posted
May 12, 2009
Registry last updated
Apr 2, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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