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NCT Number: NCT06334601

Diurnal Evaluation of OSA Upper Airway Collapsibility and Muscle Responsiveness

In the framework of pathophysiological trait in obstructive sleep apnea (OSA) patients, a simplified method is proposed to measure upper airway (UA) collapsibility and muscle responsiveness during wakefulness.

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Key information

Conditions

Obstructive Sleep Apnea Apnea Dyssomnias Nervous System Diseases Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

IRCCS Istituto Auxologico Italiano,Ospedale San Luca

Milan, 20145, Italy

Location status: Recruiting

Location contact

Elisa Perger, MD

CONTACT

[email protected]

+390261911 ext. 2705

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Obstructive Sleep Apnea (OSA)
  • At home-polygraphy with at least one EEG channel (PSG) reporting moderate-to severe obstructive sleep apnea (apnea-hypopnea index >14).

Exclusion criteria

  • OSA treatment ongoing during two weeks before PSG
  • Unstable cardio-respiratory disease in the 3 months before enrollment
  • Subjects in O2 treatment

Treatment and study plan

Tests of upper airway collapsibility and muscle responsiveness.

Diagnostic Test

Upper airway collapsibility, upper airway muscle responsiveness and loop gain will be assessed during single study visit.

Polysomnography

Primary outcomes

  1. Upper airway collapsibility

    Time frame: During the diagnostic test

    Evaluation during wakefulness

  2. Upper airway muscle responsiveness

    Time frame: During the diagnostic test

    Evaluation during wakefulness

Study contacts

Contact information is provided by the study sponsor or research team.

Elisa Perger, MD

CONTACT

[email protected]

+390261911 ext. 2705

Sponsors and collaborators

Lead sponsor

Istituto Auxologico Italiano

Other

Registry information

Official study title

Diurnal Evaluation of Obstructive Sleep Apnea (OSA) Upper Airway Collapsibility and Muscle Responsiveness

Acronym: Muscle-OSA

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Mar 28, 2024
Registry last updated
Apr 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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