Diurnal and Nocturnal Effect of Travatan With SofZia Preservative on Intraocular Pressure and Ocular Perfusion Pressure

The investigators hypothesize that Travatan Z will significantly lower intraocular pressure and increase ocular perfusion pressure during both the diurnal and nocturnal period, during a 24-hour evaluation, compared to baseline. The investigators further hypothesize that the medication effects will persist at 72 hours after discontinuation of the drug.

Inclusion criteria

• Diagnosis of open-angle glaucoma or ocular hypertension, including pigment dispersion glaucoma and pseudoexfoliation glaucoma
• Age ≥ 18 or ≤ 90 years, of either gender, or any race/ethnicity

Exclusion criteria

• Females who are currently pregnant or planning to become pregnant, as determined by history during the study period
• Diagnosis of any other form of glaucoma other than open-angle
• Schaffer angle grade < 2 in either eye by gonioscopy
• Chronic, recurrent, or severe inflammatory eye disease
• Intraocular surgery within 6 months or laser within 3 months
• History of active, recurrent, or chronic ocular infection with the Herpes Simplex Virus
• History of cystoid macular edema
• Inability to safely discontinue all ocular medications for 4 weeks
• Patients who smoke or have irregular daily sleep patterns
• Patients who have started or changed glucocorticoids therapy in the last 3 months
• Patients who are currently undergoing medical marijuana therapy
• Any use of a non-FDA approved medication for glaucoma in the last 3 months