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Completed

NCT Number: NCT06207201

Discover In-Hospital Cardiac Arrest

The Discover In-Hospital Cardiac Arrest (IHCA) study is a multicenter, prospective observational study aimed at better understanding variations in practice for the post-in-hospital cardiac arrest patient.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Montefiore Medical Center

The Bronx, New York, 10467, United States

About this study

There is considerable debate among experts concerning many components of intra- and post-arrest care. This study aims to increase the evidence base of these components, particularly temperature control, and prognostication in post-in-hospital cardiac arrest patients. In addition to providing insights regarding immediate and long-term post-arrest care, data collected will also be useful in studying variations in cardiopulmonary resuscitation practices.

This project is endorsed by the Society of Critical Care Medicine's (SCCM) Discovery, the Critical Care Research Network.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult (≥18 years old) patients
  • Patients with a cardiac arrest (a lack of palpable pulse or perfusing cardiac activity) while admitted to the hospital
  • Patients admitted to a ward (telemetry or non-telemetry) or an intensive care unit, or are admitted but still in the emergency department waiting for a hospital bed
  • Patients who achieved return of spontaneous circulation (ROSC defined as >20 minutes of sustained spontaneous circulation) OR initiated on extracorporeal membrane oxygenation (eCPR) with chest compressions ongoing
  • Patients survived for 6 hours after ROSC

Exclusion criteria

  • Cardiac arrest in non-inpatients (e.g. outpatients, visitors)
  • Patients whose cardiopulmonary resuscitation (CPR) starts outside of the hospital
  • Non-index arrests (arrests that are not the patient's first arrest during the hospital admission; this also excludes patients who were initially admitted for an out-of-hospital cardiac arrest)
  • Patients suffering IHCA in the operating room (OR) or post anesthesia care unit (PACU)
  • Patients with cardiac arrest after arriving to an emergency department (ED) but prior to being evaluated and admitted to the hospital
  • Cardiac arrests lasting <2 minutes (i.e. chest compressions performed <2 minutes)
  • Cardiac arrests where the patient is transitioned to comfort focused care within 6 hours of return of spontaneous circulation (ROSC)

Treatment and study plan

Primary outcomes

  1. Fever Incidence

    Time frame: Up to 96-hours post cardiac arrest

    The incidence of fever from ROSC until 96 hours after ROSC among patients who remain comatose

  2. Multimodal Prognostication

    Time frame: Up to 60 days post cardiac arrest

    The use of at least two approaches for prognostication prior to withdrawal of care from ROSC until hospital discharge

  3. Early Withdrawal of Care

    Time frame: Up to 72-hours post cardiac arrest

    The withdrawal of care from ROSC until 72-hour after ROSC

Sponsors and collaborators

Lead sponsor

Montefiore Medical Center

Other

Collaborators

  • Society of Critical Care Medicine

Registry information

Official study title

Discover In-Hospital Cardiac Arrest: A Prospective Multicenter Study of Post-In-Hospital Cardiac Arrest Management Practices

Acronym: Discover IHCA

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jan 16, 2024
Registry last updated
Nov 14, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.