University Rouen Hospital
Rouen, 76031, France
Location status: Recruiting
NCT Number: NCT07177391
Cardiac output (CO) monitoring is recommended for the most serious and multiple-failure patients in critical care and allows the diagnosis of acute circulatory failure as well as its etiology and also allows the monitoring of treatments. However, although allowing an adaptation of hemodynamic treatments and being integrated into a therapeutic personalization approach in situations of acute circulatory failure, the measurement of CO is conditioned by the availability of devices, by their sometimes problematic invasiveness, as well as their cost. In addition, the discontinuous measurement of CO by echocardiography is made difficult in the context of resuscitation with patients who are less mobilizable and less echogenic.
Interested in participating?
Request Info18 year and older
All sexes
Observational
Rouen, 76031, France
Location status: Recruiting
The subcostal assessment route is the classic emergency route. It allows for the analysis of the basic segmental kinetics of the left ventricle, an analysis of the Left Ventricular Ejection Fraction (LVEF), the search for pericardial effusion or even tamponade, or the search for right ventricular dilation. A measurement of CO via the right ventricular outflow tract using transthoracic echocardiography has never been described in the literature, although it is feasible, based on the same mathematical rationale as the standard measurement of cardiac output via the left ventricular outflow tract (which takes into account the diameter of the outflow tract and the subvalvular time-velocity integral [TVI]).
Since at all times the left (systemic) CO is equal to the right (venous return) CO, it is therefore possible to consider a measurement of CO via the subcostal route. By not complicating the standard care of patients in critical care, especially in situations of acute circulatory failure, and by adding only a few seconds or even minutes to an examination already recommended and routine in critical care, this evaluation approach seems interesting given the need and the recommendations in force on the monitoring of patients in intensive care and more particularly of DC.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Right Ventricular Outflow Chamber Diameter (RVOD) and Left Ventricular Outflow Chamber Diameter (LVOD) assessments via subcostal approach
Time frame: At Enrollment visit and DAY 28
To assess the concordance of the measurement of cardiac output in the ejection chamber of the right ventricle (DC-CEVD, innovative method) with that of cardiac output in the ejection chamber of the left ventricle (DC-CEVG, reference method) on subcostal transthoracic ultrasound (TTE).
Time frame: At Enrollment visit and DAY 28
Evaluate the success of cardiac output measurement, defined by the fact of rendering a flow measurement
Time frame: At Enrollment visit and DAY 28
Evaluation of DC Variation during the preload-dependence search maneuver: passive leg raise test and 1-minute DC measurement according to the two modalities (DC-CEVD and DC-CEVG measurements).
Time frame: At Enrollment visit and DAY 28
Search for the best concordance of the DC-CEVD to the Plan for Continuity of Circulation and Oxygenation (PCCO) and of the DC-CEVG to the PCCOi in a patient who has a transpulmonary thermodilution device with analysis of the pulse wave contour (PCCO), (PiCCO2),
Contact information is provided by the study sponsor or research team.
University Hospital, Rouen
Other
Discontinuous Echocardiographic Subcostal Cardiac Output Measurement by the Right Ventricular Outflow Tract in Critical Care
Acronym: RIGHT WAY
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