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NCT Number: NCT07177391

Discontinuous Echocardiographic Subcostal Cardiac Output Measurement

Cardiac output (CO) monitoring is recommended for the most serious and multiple-failure patients in critical care and allows the diagnosis of acute circulatory failure as well as its etiology and also allows the monitoring of treatments. However, although allowing an adaptation of hemodynamic treatments and being integrated into a therapeutic personalization approach in situations of acute circulatory failure, the measurement of CO is conditioned by the availability of devices, by their sometimes problematic invasiveness, as well as their cost. In addition, the discontinuous measurement of CO by echocardiography is made difficult in the context of resuscitation with patients who are less mobilizable and less echogenic.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Rouen Hospital

Rouen, 76031, France

Location status: Recruiting

Location contact

Thomas TM MAUDHUIZON, Doctor

CONTACT

[email protected]

02 32 88 82 61 ext. +33

About this study

The subcostal assessment route is the classic emergency route. It allows for the analysis of the basic segmental kinetics of the left ventricle, an analysis of the Left Ventricular Ejection Fraction (LVEF), the search for pericardial effusion or even tamponade, or the search for right ventricular dilation. A measurement of CO via the right ventricular outflow tract using transthoracic echocardiography has never been described in the literature, although it is feasible, based on the same mathematical rationale as the standard measurement of cardiac output via the left ventricular outflow tract (which takes into account the diameter of the outflow tract and the subvalvular time-velocity integral [TVI]).

Since at all times the left (systemic) CO is equal to the right (venous return) CO, it is therefore possible to consider a measurement of CO via the subcostal route. By not complicating the standard care of patients in critical care, especially in situations of acute circulatory failure, and by adding only a few seconds or even minutes to an examination already recommended and routine in critical care, this evaluation approach seems interesting given the need and the recommendations in force on the monitoring of patients in intensive care and more particularly of DC.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patient (Age ≥ 18 years)
  • Patient admitted to the intensive care unit at Rouen University Hospital.
  • Transthoracic echocardiography (TTE) is required upon admission or during the patient's stay for diagnostic assessment and/or therapeutic monitoring.

Exclusion criteria

  • Person deprived of liberty by an administrative or judicial decision or person placed under judicial protection/guardianship or curatorship
  • Patient not affiliated with the social security system
  • Refusal by the patient or trusted person if the patient is incapable of expressing consent
  • Pregnant woman
  • Dying patient

Treatment and study plan

Discontinuous subcostal echocardiographic cardiac output assessment

Other

Right Ventricular Outflow Chamber Diameter (RVOD) and Left Ventricular Outflow Chamber Diameter (LVOD) assessments via subcostal approach

Primary outcomes

  1. Measurement of Cardiac Output (CO) via the subcostal route

    Time frame: At Enrollment visit and DAY 28

    To assess the concordance of the measurement of cardiac output in the ejection chamber of the right ventricle (DC-CEVD, innovative method) with that of cardiac output in the ejection chamber of the left ventricle (DC-CEVG, reference method) on subcostal transthoracic ultrasound (TTE).

Secondary outcomes

  1. Compare the measurement success rate of DC-CEVD to that of DC-CEVG.

    Time frame: At Enrollment visit and DAY 28

    Evaluate the success of cardiac output measurement, defined by the fact of rendering a flow measurement

  2. To assess the concordance of DC variation during preload-dependence search maneuvers (passive leg raise) in intubated and ventilated patients between DC-CEVD and DC-CEVG measurements.

    Time frame: At Enrollment visit and DAY 28

    Evaluation of DC Variation during the preload-dependence search maneuver: passive leg raise test and 1-minute DC measurement according to the two modalities (DC-CEVD and DC-CEVG measurements).

  3. DC measurement by transpulmonary thermodilution device

    Time frame: At Enrollment visit and DAY 28

    Search for the best concordance of the DC-CEVD to the Plan for Continuity of Circulation and Oxygenation (PCCO) and of the DC-CEVG to the PCCOi in a patient who has a transpulmonary thermodilution device with analysis of the pulse wave contour (PCCO), (PiCCO2),

Study contacts

Contact information is provided by the study sponsor or research team.

Thomas TM MAUDHUIZON, Doctor

CONTACT

[email protected]

02 32 88 82 61 ext. +33

Sponsors and collaborators

Lead sponsor

University Hospital, Rouen

Other

Registry information

Official study title

Discontinuous Echocardiographic Subcostal Cardiac Output Measurement by the Right Ventricular Outflow Tract in Critical Care

Acronym: RIGHT WAY

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 17, 2025
Registry last updated
Sep 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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